GNH USA

Europe — EMA

Korylan (Paracetamol, Codeine Phosphate Hemihydrate)

GNH USA supplies Korylan (Paracetamol and Codeine), a combination analgesic for mild to moderate pain and fever. Request a quote for global supply today.

Paracetamol, Codeine Phosphate Hemihydrate

Request sourcing

1
Pack/s

What is Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol and Codeine Phosphate Hemihydrate, the active ingredient in Korylan, is a combination analgesic presented as an oral tablet for oral use. It is indicated for the relief of mild to moderate pain and the reduction of fever in adult patients.

GNH USA supplies Korylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Paracetamol, Codeine Phosphate Hemihydrate used for?

Korylan, a combination analgesic, is employed across several common pain‑related conditions and febrile states.

- Mild to moderate pain: provides effective analgesia for everyday aches. - Fever: lowers elevated body temperature. - Post‑operative discomfort: assists in managing surgical pain. - Dental pain: alleviates discomfort after dental procedures. - Musculoskeletal pain: eases aches associated with strains or sprains. - Headache: reduces intensity of tension‑type headaches.

What are the side effects of Paracetamol, Codeine Phosphate Hemihydrate?

Korylan may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects: - Nausea - Constipation - Dizziness - Drowsiness - Vomiting - Sweating

Serious or Rare Side Effects: - Respiratory depression - Severe allergic reaction (anaphylaxis) - Hepatic injury - Dependence or addiction - Marked hypotension - Seizures (rare)

What precautions apply to Paracetamol, Codeine Phosphate Hemihydrate?

Before prescribing Korylan, clinicians should consider several safety factors.

- Liver function: assess hepatic status, especially in patients with chronic liver disease. - Renal function: evaluate kidney health, as metabolites are renally excreted. - Respiratory conditions: avoid in patients with severe respiratory depression or uncontrolled asthma. - Concomitant CNS depressants: use caution when combined with alcohol, benzodiazepines, or other opioids. - Dependence risk: monitor for signs of misuse or addiction. - Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

What does Paracetamol, Codeine Phosphate Hemihydrate interact with?

Korylan can interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Other opioid analgesics: additive risk of respiratory depression. - Benzodiazepines: increased sedation and respiratory compromise. - Alcohol: enhanced central nervous system depression.

Moderate Interactions (Monitor Closely): - CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may reduce conversion of codeine to morphine, lowering analgesic effect. - CYP3A4 inducers (e.g., rifampicin, carbamazepine): may decrease overall efficacy. - Anticholinergic agents: may exacerbate constipation. - Diuretics: can increase the likelihood of hypotension.

Frequently asked questions

What is Korylan used for?+
Korylan is a prescription‑only oral tablet that combines paracetamol and codeine phosphate hemihydrate. It is used to relieve mild to moderate pain, such as headaches, dental pain, musculoskeletal aches, and postoperative discomfort, and to reduce fever in adult patients.
How does paracetamol and codeine work in Korylan?+
Paracetamol reduces pain and fever by centrally inhibiting cyclo‑oxygenase enzymes, lowering prostaglandin production. Codeine phosphate hemihydrate is converted in the liver to morphine, which activates μ‑opioid receptors in the brain and spinal cord, providing additional analgesia and a mild cough‑suppressant effect.
What is the usual dose of Korylan?+
The specific dose of Korylan is determined by the prescribing clinician based on the individual’s age, weight, pain severity, and overall health status. Healthcare professionals follow local prescribing guidelines and adjust the regimen as needed for safety and efficacy.
Is Korylan safe to use during pregnancy or while breastfeeding?+
Safety of Korylan in pregnancy and lactation has not been definitively established. Paracetamol is generally considered low‑risk, but codeine may pose risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential benefits and risks with their healthcare provider.
How do I order Korylan from GNH USA?+
To order Korylan, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements if applicable) and necessary import documentation.
How does Korylan compare with other analgesic options?+
Compared with non‑opioid analgesics such as ibuprofen, Korylan adds an opioid component that can provide stronger pain relief for moderate pain but carries a higher risk of dependence and respiratory depression. Pure codeine products lack the antipyretic benefit of paracetamol. The choice depends on pain intensity, patient comorbidities, and risk‑benefit assessment by the prescriber.
How should Korylan be stored and handled?+
Korylan tablets should be stored at room temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use after the expiry date printed on the packaging.
How is Korylan administered?+
Korylan is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not chewed or crushed, unless a healthcare professional advises otherwise. It is typically taken with or without food, as directed by the prescriber.
What are the most serious risks associated with Korylan?+
The most serious risks include respiratory depression, especially in patients with compromised breathing, severe allergic reactions (anaphylaxis), hepatic injury from paracetamol overdose, and the potential for dependence, abuse, or addiction related to the codeine component. Prompt medical attention is required if any of these symptoms appear.
Who should not use Korylan?+
Korylan should be avoided in individuals with known hypersensitivity to paracetamol, codeine, or any excipients, in patients with severe respiratory depression, uncontrolled asthma, or acute head injury. It is also contraindicated in children under 12 years of age and in patients taking monoamine oxidase inhibitors within two weeks of therapy.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Paracetamol, Codeine Phosphate Hemihydrate
Route
Oral Use
Manufacturer
Zentiva, K.S.
Origin
EU

Related products

Algocalm

Algocalm

Paracetamol, Codeine Phosphate Hemihydrate

Zentiva, K.S.
EU
Altermol

Altermol

Paracetamol, Codeine Phosphate Hemihydrate

Alternova A/S
EU
Altermol

Altermol

Paracetamol, Codeine Phosphate Hemihydrate

Alternova A/S
EU
Analgiplus

Analgiplus

Paracetamol, Codeine Phosphate Hemihydrate

Faes Farma, S.A.
EU