Korandil

Enalapril, the active ingredient in Korandil, is an ACE inhibitor presented as an oral dosage form for oral use. It is used to treat hypertension, heart failure, and post‑myocardial infarction left ventricular dysfunction in adult patients.

GNH USA supplies Korandil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Enalapril is an ACE inhibitor that acts on the renin‑angiotensin‑aldosterone system to manage cardiovascular conditions. - Hypertension: lowers systemic blood pressure and reduces risk of stroke and heart attack. - Heart failure: improves cardiac output and decreases symptoms of fluid overload. - Post‑myocardial infarction left ventricular dysfunction: helps prevent remodeling and further cardiac events.

Enalapril may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Cough: dry, persistent throat irritation. - Dizziness: especially upon standing. - Headache: mild to moderate intensity. - Fatigue: general feeling of tiredness. - Hyperkalemia: elevated blood potassium levels. - Renal function changes: modest increase in serum creatinine.

Serious or Rare Side Effects: - Angioedema: swelling of face, lips, tongue, or airway. - Severe hypotension: marked drop in blood pressure. - Acute kidney injury: rapid decline in renal function. - Hepatotoxicity: abnormal liver enzymes. - Neutropenia: low white blood cell count. - Stevens‑Johnson syndrome: severe skin reactions.

Before initiating therapy, consider patient‑specific factors and monitor appropriately. - Pregnancy: contraindicated in the second and third trimesters due to fetal toxicity. - Renal impairment: adjust dose and monitor creatinine and electrolytes. - Hyperkalemia risk: avoid concurrent potassium‑sparing diuretics or supplements. - Hypotension: caution in patients with volume depletion or on diuretics. - Drug-specific monitoring: regular blood pressure and renal function checks. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Enalapril can interact with several drug classes, affecting efficacy or safety.

Major Interactions (Avoid): - Aliskiren: combined use in diabetes or renal impairment may increase risk of renal dysfunction. - Lithium: may increase lithium levels, leading to toxicity. - Potassium‑sparing diuretics or supplements: can precipitate severe hyperkalemia.

Moderate Interactions (Monitor Closely): - Non‑steroidal anti‑inflammatory drugs (NSAIDs): may blunt antihypertensive effect and impair renal function. - Diuretics: may cause additive hypotensive effect, especially during initiation. - Antihyperglycemics: may enhance hypoglycemic response. - Rifampin: may reduce enalapril plasma concentrations. - Certain antibiotics (e.g., trimethoprim): can increase potassium levels.