Kolistin Zentiva

Colistimethate sodium, the active ingredient in Kolistin Zentiva, is a Polymyxin antibiotic presented as a sterile solution for inhalation and intravenous use. It treats serious infections caused by susceptible Gram‑negative bacteria, including Pseudomonas aeruginosa, in hospitalized patients. GNH USA supplies Kolistin Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Kolistin Zentiva is a Polymyxin antibiotic used to treat serious Gram‑negative bacterial infections. - Pseudomonas aeruginosa infection: provides effective therapy for severe infections caused by susceptible strains. - Ventilator‑associated pneumonia: used in critically ill patients with VAP due to susceptible Gram‑negative organisms. - Other Gram‑negative bacterial infections: indicated when the pathogen is confirmed susceptible to colistimethate sodium.

Colistin therapy may be associated with a range of adverse reactions.

Common Side Effects: - Nephrotoxicity: elevated serum creatinine and reduced glomerular filtration rate. - Neurotoxicity: paresthesia, dizziness, or visual disturbances. - Respiratory irritation: cough or bronchospasm when inhaled. - Gastrointestinal upset: nausea, vomiting, or abdominal pain.

Serious or Rare Side Effects: - Acute kidney injury requiring dialysis. - Seizures or severe central nervous system toxicity. - Anaphylactic reactions: hives, swelling, or respiratory compromise.

Colistin should be used with careful monitoring and adherence to safety guidelines. - Renal function monitoring: assess serum creatinine before and during therapy. - Neurological assessment: watch for signs of neurotoxicity, especially in high‑dose regimens. - Dose adjustment: modify dosage in patients with impaired renal function. - Concomitant nephrotoxic drugs: avoid or closely monitor when used together. - Pregnancy and lactation: use only if the potential benefit justifies the potential risk. Store below 25°C: keep in the original container, protect from moisture and light.

Colistin may interact with other medicines, requiring vigilance.

Major Interactions (Avoid): - Aminoglycosides: combined nephrotoxic effect may lead to severe kidney injury. - Loop diuretics: increase risk of renal impairment when used together.

Moderate Interactions (Monitor Closely): - Non‑steroidal anti‑inflammatory drugs (NSAIDs): may potentiate nephrotoxicity. - Neuromuscular blocking agents: can enhance neuromuscular blockade, leading to respiratory depression. - Other nephrotoxic agents: monitor renal function closely when co‑administered.