Knavon Retard

Ketoprofen, the active ingredient in Knavon Retard, is a Nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for oral use. It is used to relieve mild to moderate pain and to treat inflammatory conditions such as osteoarthritis, rheumatoid arthritis and other musculoskeletal disorders.

GNH USA supplies Knavon Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen acts on inflammatory pathways and is indicated for several painful and inflammatory conditions.

- Osteoarthritis: reduces joint pain and improves mobility. - Rheumatoid arthritis: alleviates inflammation and joint tenderness. - Musculoskeletal pain: provides analgesia for strains, sprains and back pain. - Acute mild to moderate pain: relieves pain from dental procedures, postoperative settings or injury.

Ketoprofen may cause a range of adverse reactions, from mild to serious.

Common Side Effects: - Gastrointestinal discomfort: dyspepsia, nausea or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin rash or pruritus.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Acute renal impairment or failure. - Severe skin reactions such as Stevens‑Johnson syndrome. - Anaphylactic or anaphylactoid reactions. - Hepatic dysfunction with elevated transaminases.

Before prescribing Ketoprofen, clinicians should consider several safety aspects.

- Renal function: assess baseline kidney status and monitor during therapy. - Gastrointestinal risk: avoid in patients with a history of ulcers or bleeding. - Cardiovascular disease: use cautiously in patients with hypertension or heart disease. - Concomitant NSAIDs or anticoagulants: increase bleeding risk. - Pregnancy and lactation: evaluate risk‑benefit; use only if clearly needed. - Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Ketoprofen can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened risk of serious bleeding. - High‑dose aspirin or other NSAIDs: increased gastrointestinal toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or diuretics: possible reduction in renal function. - Lithium: NSAIDs may raise lithium serum levels. - Methotrexate: reduced clearance may lead to toxicity.