Knavon

Ketoprofen, the active ingredient in Knavon, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is employed to relieve mild to moderate pain and to reduce inflammation in conditions such as rheumatoid arthritis, osteoarthritis and other musculoskeletal disorders. GNH USA supplies Knavon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen acts on inflammatory pathways to provide analgesic and anti‑inflammatory benefits in several common conditions. - Mild to moderate pain: reduces pain intensity and improves functional comfort. - Rheumatoid arthritis: alleviates joint inflammation and swelling. - Osteoarthritis: diminishes joint pain and stiffness. - Musculoskeletal pain: eases strain‑related discomfort and improves mobility.

Ketoprofen may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin rash or mild itching. - Elevated liver enzymes.

Serious or Rare Side Effects: - Peptic ulcer disease or gastrointestinal bleeding. - Severe renal impairment or acute kidney injury. - Cardiovascular events such as myocardial infarction or stroke. - Severe hypersensitivity reactions including Stevens‑Johnson syndrome. - Hepatotoxicity with jaundice or hepatitis.

Before using Ketoprofen, consider the following safety measures. - Assess renal function: avoid use in severe kidney disease. - Evaluate gastrointestinal risk: patients with ulcer history should use caution. - Monitor cardiovascular status: avoid in uncontrolled hypertension or recent heart events. - Review concomitant NSAID or anticoagulant therapy to reduce bleeding risk. - Pregnancy and lactation: discuss with a healthcare professional before use. - Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture and direct sunlight.

Ketoprofen can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Selective COX‑2 inhibitors: heightened gastrointestinal toxicity. - High‑dose aspirin: additive renal and gastric adverse effects.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce antihypertensive effect and impair renal function. - Diuretics: potential for decreased kidney perfusion. - Lithium: NSAIDs can raise lithium serum levels, risking toxicity.