GNH USA

Europe — EMA

Klotrimazol Polpharma

GNH USA supplies Klotrimazol Polpharma (Clotrimazole), an azole antifungal for dermatophyte infections and candidiasis. Request a quote for supply.

Clotrimazole

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What is Clotrimazole?

Clotrimazole, the active ingredient in Klotrimazol Polpharma, is a azole antifungal presented as a topical formulation for skin application. It treats fungal skin infections such as athlete’s foot, ringworm and yeast‑related dermatitis in patients of all ages. It is indicated for both superficial and cutaneous fungal infections and is well‑tolerated when applied as directed.

GNH USA supplies Klotrimazol Polpharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with European Union quality standards and is manufactured under strict Good Manufacturing Practice guidelines.

What is Clotrimazole used for?

Clotrimazole is an azole antifungal used to treat superficial fungal infections of the skin.

- Dermatophyte infections (tinea corporis, tinea cruris, tinea pedis): Reduces fungal growth and clears the rash, itching and scaling associated with these conditions. - Cutaneous candidiasis: Eliminates Candida species on the skin, relieving erythema, soreness and discharge. - Seborrheic dermatitis: Controls Malassezia yeast overgrowth, improving flaking and redness of affected areas.

What are the side effects of Clotrimazole?

Clotrimazole may cause local skin reactions, most of which are mild and reversible.

Common Side Effects: - Burning sensation: Transient feeling of heat at the application site. - Itching: Mild pruritus that usually resolves with continued use. - Redness: Local erythema around the treated area. - Dryness or peeling: Slight skin flaking after treatment.

Serious or Rare Side Effects: - Contact dermatitis: Allergic skin reaction with swelling, vesicles or intense itching. - Severe skin irritation: Persistent pain, ulceration or extensive rash requiring medical attention.

What precautions apply to Clotrimazole?

Before using Klotrimazol Polpharma, consider the following precautions to ensure safe and effective treatment.

- Application area: Apply only to intact skin and avoid eyes, mouth or mucous membranes. - Allergy history: Discontinue use if signs of allergic contact dermatitis develop. - Age restrictions: Use in children under 2 years only under medical supervision. - Concomitant skin products: Do not apply other topical medications on the same area unless advised. - Store at room temperature: Keep below 25 °C, in the original container, protected from moisture and direct sunlight.

What does Clotrimazole interact with?

Clotrimazole can interact with other topical agents and, rarely, with systemic drugs that affect skin metabolism.

Major Interactions (Avoid): - Other antifungal creams: Simultaneous use may increase risk of skin irritation. - Topical corticosteroids: May reduce antifungal efficacy when applied together.

Moderate Interactions (Monitor Closely): - Occlusive dressings: Enhance drug absorption and could increase local irritation. - Systemic azole antifungals: May lead to additive hepatic enzyme inhibition if large skin areas are treated extensively. - Alcohol-based cleansers: Can alter drug solubility and affect absorption.

Frequently asked questions

What is Klotrimazol Polpharma used for?+
Klotrimazol Polpharma is a topical clotrimazole product indicated for the treatment of superficial fungal skin infections. It is commonly used to manage dermatophyte conditions such as tinea corporis, tinea cruris and tinea pedis, as well as cutaneous candidiasis and seborrheic dermatitis caused by yeast overgrowth.
How does clotrimazole work?+
Clotrimazole works by inhibiting the fungal enzyme lanosterol 14α‑demethylase, which is essential for ergosterol synthesis. By blocking this step, the drug disrupts the fungal cell membrane, leading to loss of membrane integrity, impaired growth and ultimately cell death of the pathogenic fungus.
What is the usual dose of Klotrimazol Polpharma?+
The specific dosing regimen for Klotrimazol Polpharma is determined by the prescribing healthcare professional. Typically, a thin layer of the cream or ointment is applied to the affected skin area once or twice daily, but exact frequency and duration should follow the prescriber’s instructions.
Is Klotrimazol Polpharma safe in pregnancy or breastfeeding?+
Safety data for clotrimazole use during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their physician before using the medication.
How do I order Klotrimazol Polpharma from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.
How does Klotrimazol Polpharma compare with other topical antifungals?+
Klotrimazol Polpharma (clotrimazole) belongs to the azole class and offers broad-spectrum activity against dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, clotrimazole generally has a similar efficacy for many skin infections but may be preferred for its lower cost and wide availability as an OTC product.
What are the storage and handling requirements for Klotrimazol Polpharma?+
Store Klotrimazol Polpharma at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use to maintain stability.
How is Klotrimazol Polpharma administered?+
The medication is applied topically to clean, dry skin. A thin layer should be spread over the affected area and gently rubbed in. The treated skin should be left uncovered unless directed otherwise, and the application schedule should follow the prescribing clinician’s guidance.
What are the most serious risks associated with Klotrimazol Polpharma?+
Although rare, serious adverse reactions can include allergic contact dermatitis, which may present with swelling, vesicles, intense itching or a spreading rash. If any signs of severe skin irritation or an allergic response develop, the product should be discontinued and medical advice sought promptly.
Who should not use Klotrimazol Polpharma?+
Individuals with a known hypersensitivity to clotrimazole or any other component of the formulation should avoid using the product. It is also contraindicated on broken or severely inflamed skin, and caution is advised when applying to large body surface areas without medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Clotrimazole
Route
Cutaneous Use
Manufacturer
Zaklady Farmaceutyczne Polpharma S.A.
Origin
EU

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