GNH USA

Europe — EMA

Klotrimazol Pliva

GNH USA supplies Klotrimazol Pliva (Clotrimazole), a topical imidazole antifungal for dermatophytic and candidal skin infections.

Clotrimazole

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What is Clotrimazole?

Clotrimazole, the active ingredient in Klotrimazol Pliva, is an imidazole antifungal presented as a topical formulation for skin application. It treats dermatophytic and candidal skin infections in adults and children. GNH USA supplies Klotrimazol Pliva as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Clotrimazole used for?

Clotrimazole is an imidazole antifungal used topically to manage dermatophytic and candidal skin infections. - Tinea corporis (ringworm of the body): reduces fungal growth and clears lesions. - Tinea pedis (athlete's foot): alleviates itching and eliminates infection. - Tinea cruris (jock itch): treats the fungal cause and improves skin condition. - Candidal skin infection (cutaneous candidiasis): eradicates Candida species from affected areas.

What are the side effects of Clotrimazole?

Common side effects are generally mild and limited to the site of application.

Common Side Effects: - Mild skin irritation: transient redness or discomfort at the application site. - Burning sensation: brief feeling of heat after applying the product. - Itching: occasional pruritus localized to treated area. - Redness: slight erythema that usually resolves quickly.

Serious or Rare Side Effects: - Severe allergic reaction (angioedema, anaphylaxis): requires immediate medical attention. - Contact dermatitis: intense skin inflammation due to hypersensitivity. - Skin blistering: formation of vesicles or bullae at the site. - Photosensitivity: increased skin sensitivity to sunlight.

What precautions apply to Clotrimazole?

Before using Klotrimazol Pliva, consider the following safety measures. - Allergy assessment: avoid use if known hypersensitivity to clotrimazole or other imidazoles. - Pregnancy: safety not established; consult a healthcare professional before use. - Breastfeeding: limited data; weigh benefits against potential risks. - Application area: limit to affected skin; avoid eyes, mucous membranes, and broken skin. - Store at room temperature: keep in original container, protect from moisture and direct sunlight.

What does Clotrimazole interact with?

Clotrimazol Pliva may interact with other topical agents; monitor for combined effects.

Major Interactions (Avoid): - Concurrent use with systemic azole antifungals: may increase systemic exposure. - Use with topical corticosteroids: may reduce antifungal efficacy.

Moderate Interactions (Monitor Closely): - Use with other irritant skin products: may increase local irritation. - Use with occlusive dressings: may enhance percutaneous absorption. - Application on damaged skin: monitor for increased systemic absorption.

Frequently asked questions

What is Klotrimazol Pliva used for?+
Klotrimazol Pliva is a topical clotrimazole preparation indicated for the treatment of superficial fungal infections of the skin, including tinea corporis, tinea pedis, tinea cruris, and cutaneous candidiasis. It works by eliminating the fungi that cause these conditions, helping to relieve symptoms such as itching, redness, and scaling.
How does clotrimazole work?+
Clotrimazole belongs to the imidazole class of antifungals. It blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for converting lanosterol to ergosterol, a key component of the fungal cell membrane. Without ergosterol, the membrane becomes defective, leading to inhibited growth and death of the fungus.
What is the usual dose of Klotrimazol Pliva?+
The dosing regimen for Klotrimazol Pliva is determined by the prescribing healthcare professional based on the type and severity of the infection, the patient’s age, and other clinical factors. Patients should follow the prescriber’s instructions regarding the amount to apply, frequency, and duration of therapy.
Is Klotrimazol Pliva safe in pregnancy or breastfeeding?+
Safety data for clotrimazole use during pregnancy and lactation are limited. The product should be used only if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss the use of Klotrimazol Pliva with their healthcare provider.
How do I order Klotrimazol Pliva from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity of Klotrimazol Pliva. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After verification, the team provides pricing, availability, shipping details, and any necessary import documentation.
How does Klotrimazol Pliva compare with other antifungal options?+
Klotrimazol Pliva (clotrimazole) is an imidazole antifungal that is effective against a broad range of dermatophytes and Candida species. Compared with allylamine agents such as terbinafine, clotrimazole has a similar spectrum for superficial infections but may be less potent for certain resistant strains. Choice of therapy often depends on physician preference, infection type, and patient tolerance.
How should Klotrimazol Pliva be stored and handled?+
Store Klotrimazol Pliva at room temperature, preferably below 25 °C, in its original packaging. Keep the container tightly closed to protect the product from moisture and direct sunlight. Do not freeze the cream, and keep it out of reach of children.
How is Klotrimazol Pliva applied?+
Apply a thin layer of the cream to the affected skin area, usually twice daily, unless otherwise directed by a healthcare professional. Gently rub the product into clean, dry skin and wash hands after application. Avoid contact with eyes, mouth, and mucous membranes.
What are the most serious risks associated with Klotrimazol Pliva?+
While most reactions are mild, serious adverse events can include severe allergic responses such as angioedema or anaphylaxis, extensive contact dermatitis, blistering of the skin, and photosensitivity. Patients should seek immediate medical attention if they experience swelling, difficulty breathing, widespread rash, or blister formation.
Who should not use Klotrimazol Pliva?+
Individuals with a known hypersensitivity to clotrimazole, other imidazole antifungals, or any component of the formulation should avoid using Klotrimazol Pliva. It is also contraindicated on severely damaged skin, mucous membranes, or in patients where a systemic antifungal therapy is more appropriate.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Clotrimazole
Route
Cutaneous Use
Manufacturer
Pliva Hrvatska D.O.O.
Origin
EU

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