GNH USA

Europe — EMA

Klorzoxazon Evolan

GNH USA supplies Klorzoxazon Evolan (Chlorzoxazone), a muscle relaxant for muscle spasm and musculoskeletal pain. Request a quote for global supply.

Chlorzoxazone

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What is Chlorzoxazone?

Chlorzoxazone, the active ingredient in Klorzoxazon Evolan, is a muscle relaxant presented as an oral tablet for oral use. It is prescribed to relieve muscle spasm and associated musculoskeletal pain in adult patients.

GNH USA supplies Klorzoxazon Evolan as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Chlorzoxazone used for?

Chlorzoxazone is used to treat conditions involving skeletal muscle spasm and related pain.

- Muscle spasm: reduces the intensity and frequency of involuntary muscle contractions. - Acute low back pain: alleviates pain associated with muscle strain. - Musculoskeletal pain: provides relief from pain caused by muscle injury or overuse.

What are the side effects of Chlorzoxazone?

Chlorzoxazone may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Drowsiness - Dizziness - Headache - Nausea - Fatigue - Gastrointestinal upset

Serious or Rare Side Effects: - Severe skin reactions such as Stevens-Johnson syndrome - Hepatotoxicity or liver enzyme elevation - Blood dyscrasias including agranulocytosis - Anaphylactic allergic reactions - Hemolytic anemia - Severe hypotension

What precautions apply to Chlorzoxazone?

When prescribing chlorzoxazone, clinicians should consider several safety factors. - Pregnancy: safety not established; use only if benefits outweigh risks. - Liver disease: use with caution and monitor hepatic function. - Renal impairment: dose adjustment may be required. - Concomitant CNS depressants: may enhance sedative effects. - Alcohol consumption: can increase drowsiness and dizziness. - Store at ambient temperature below 25°C: keep in original packaging, protect from moisture.

What does Chlorzoxazone interact with?

Chlorzoxazone can interact with a variety of medicines, requiring careful management.

Major Interactions (Avoid): - CNS depressants (e.g., benzodiazepines, opioids): may cause profound sedation. - Alcohol: additive CNS depression. - Monoamine oxidase inhibitors: risk of enhanced hypotension. - Antihistamines: increased drowsiness. - Anticonvulsants (e.g., carbamazepine): may reduce efficacy.

Moderate Interactions (Monitor Closely): - Warfarin: possible alteration of anticoagulant effect. - Theophylline: may increase risk of toxicity. - CYP2C9 substrates: potential metabolic interaction. - Anticholinergic agents: additive dry mouth. - Lithium: possible increased neurotoxicity.

Frequently asked questions

What is Klorzoxazon Evolan used for?+
Klorzoxazon Evolan contains chlorzoxazone, a skeletal muscle relaxant indicated for the relief of muscle spasm and associated musculoskeletal pain. It is commonly prescribed for conditions such as acute low back pain, muscle strain, and other painful musculoskeletal disorders where involuntary muscle contraction contributes to discomfort.
How does chlorzoxazone work?+
Chlorzoxazone works by centrally inhibiting polysynaptic reflex pathways in the spinal cord. This action reduces the transmission of excitatory signals to skeletal muscles, decreasing muscle tone and spasm without directly acting on the muscle fibers themselves, thereby providing relief from painful contractions.
What is the usual dose of Klorzoxazon Evolan?+
The appropriate dose of Klorzoxazon Evolan is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and response to therapy. Dosage adjustments may be needed for renal or hepatic impairment, and the prescriber will provide specific instructions.
Is Klorzoxazon Evolan safe in pregnancy or breastfeeding?+
Safety data for chlorzoxazone during pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies the potential risk to the fetus or infant. Healthcare providers typically advise caution and may recommend alternative therapies when possible.
How do I order Klorzoxazon Evolan from GNH USA?+
To order Klorzoxazon Evolan, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.
How does Klorzoxazon Evolan compare with other muscle relaxants?+
Klorzoxazon Evolan (chlorzoxazone) differs from alternatives such as cyclobenzaprine or tizanidine in its mechanism and side‑effect profile. Chlorzoxazone acts centrally on spinal reflexes, whereas cyclobenzaprine primarily affects the brainstem. Tizanidine is an alpha‑2 agonist with a higher risk of hypotension. Choice of agent depends on patient tolerance, comorbidities, and physician preference.
How should Klorzoxazon Evolan be stored and handled?+
Store Klorzoxazon Evolan at ambient temperature below 25 °C, in its original packaging, and protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to extreme temperatures or humidity, which could affect its stability.
How is Klorzoxazon Evolan administered?+
Klorzoxazon Evolan is administered orally, typically as a tablet taken with or without food as directed by the prescriber. The exact timing and whether it should be taken with meals depend on individual patient instructions and tolerability.
What are the most serious risks associated with Klorzoxazon Evolan?+
Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, hepatotoxicity leading to elevated liver enzymes or liver failure, blood dyscrasias like agranulocytosis, and rare cases of anaphylaxis. Patients should be monitored for signs of these reactions and seek immediate medical attention if they occur.
Who should not use Klorzoxazon Evolan?+
Klorzoxazon Evolan is contraindicated in patients with known hypersensitivity to chlorzoxazone or any of its excipients. It should also be avoided in individuals with severe hepatic impairment, uncontrolled epilepsy, or those taking certain contraindicated CNS depressants without medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Chlorzoxazone
Route
Oral Use
Manufacturer
Evolan Pharma Ab
Origin
EU

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