Kloramfenikol Santen

Chloramphenicol, the active ingredient in Kloramfenikol Santen, is an antibiotic presented as an ophthalmic preparation for ocular use. It treats bacterial eye infections in patients requiring topical therapy.

GNH USA supplies Kloramfenikol Santen as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Chloramphenicol is used to manage bacterial infections of the eye.

- Conjunctivitis: reduces bacterial load and alleviates ocular inflammation. - Keratitis: treats corneal bacterial infection and promotes healing. - Blepharitis: controls bacterial overgrowth on eyelid margins and improves symptoms.

Chloramphenicol may cause ocular and systemic adverse reactions.

Common Side Effects: - Eye irritation or burning sensation. - Redness of the conjunctiva. - Excessive tearing. - Foreign body sensation. - Blurred vision. - Mild localized allergic reaction.

Serious or Rare Side Effects: - Aplastic anemia or bone‑marrow suppression. - Severe allergic reactions including anaphylaxis. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Visual loss unrelated to infection. - Systemic toxicity from prolonged absorption. - Severe dermatitis.

When using chloramphenicol eye drops, consider the following precautions.

- Avoid use in patients with known hypersensitivity to chloramphenicol: discontinue immediately if reaction occurs. - Do not use for viral or fungal eye infections: confirm bacterial etiology before treatment. - Limit duration of therapy: follow prescriber guidance to reduce resistance risk. - Monitor for systemic absorption signs in prolonged use: report unusual fatigue or bruising. - Store at below 25°C: keep in original container, protect from moisture and light.

Chloramphenicol can interact with certain systemic medications and ocular agents.

Major Interactions (Avoid): - Systemic aminoglycosides: may increase ototoxicity. - Oral anticoagulants (e.g., warfarin): potential enhancement of anticoagulant effect. - Oral contraceptives: possible reduction of contraceptive efficacy.

Moderate Interactions (Monitor Closely): - Concurrent topical antibiotics: risk of additive ocular toxicity. - Non‑steroidal anti‑inflammatory eye drops: may increase irritation. - Drugs metabolized by CYP2C9 (e.g., certain NSAIDs): chloramphenicol may alter plasma levels.