Kloramfenikol

Chloramphenicol, the active ingredient in Kloramfenikol, is an amphenicol presented as a topical ophthalmic solution for ocular use. It is indicated for the treatment of bacterial eye infections such as conjunctivitis, keratitis and blepharitis in both adult and pediatric patients.

GNH USA supplies Kloramfenikol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Chloramphenicol is an antibacterial agent used in ophthalmology to manage infections of the eye surface and structures. - Conjunctivitis: reduces bacterial load and promotes resolution of inflammation. - Keratitis: treats bacterial corneal infection and aids healing. - Blepharitis: helps control bacterial involvement of the eyelid margins.

Adverse reactions may occur with ocular chloramphenicol use.

Common Side Effects: - Mild eye irritation or burning sensation. - Redness of the conjunctiva. - Transient blurred vision. - Local itching or discomfort. - Mild allergic eyelid edema. - Temporary tearing.

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) with swelling and difficulty breathing. - Stevens‑Johnson syndrome or toxic epidermal necrolysis involving the ocular surface. - Bone marrow suppression leading to aplastic anemia (systemic absorption risk). - Contact dermatitis around the peri‑ocular area. - Persistent corneal ulceration. - Vision loss due to severe ocular inflammation.

When using Kloramfenikol, consider the following safety measures. - Allergic History: avoid if known hypersensitivity to chloramphenicol or other amphenicols. - Pregnancy: use only if clearly needed; safety data are limited. - Breastfeeding: consult a healthcare professional before use. - Systemic Absorption: monitor for signs of bone‑marrow suppression, especially with prolonged therapy. - Contact Lens Wearers: remove lenses before application and wait before reinserting. - Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Chloramphenicol may interact with other agents affecting its efficacy or safety.

Major Interactions (Avoid): - Systemic aminoglycosides: increased risk of ototoxicity when absorbed. - Warfarin: potential enhancement of anticoagulant effect.

Moderate Interactions (Monitor Closely): - Other topical antibiotics: may reduce effectiveness if used concurrently. - Non‑steroidal anti‑inflammatory eye drops: monitor for additive irritation. - Corticosteroid eye drops: increased risk of secondary infection.