GNH USA

Europe — EMA

Kliogest (Norethisterone Acetate, Estradiol)

GNH USA supplies Kliogest (Norethisterone acetate and estradiol), a combined estrogen‑progestogen for contraception, menstrual regulation and treatment

Norethisterone Acetate, Estradiol

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What is Norethisterone Acetate, Estradiol?

Norethisterone acetate and estradiol, the active ingredient in Kliogest, is a combined estrogen‑progestogen presented as an oral tablet for oral use. It treats contraception, regulation of menstrual cycles, and treatment of menstrual disorders in women of reproductive age.

GNH USA supplies Kliogest as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Norethisterone Acetate, Estradiol used for?

Kliogest, a combined estrogen‑progestogen oral contraceptive, is indicated for the following conditions:

Contraception: provides reliable prevention of pregnancy. Regulation of menstrual cycles: helps achieve predictable cycle timing. Treatment of menstrual disorders: alleviates symptoms such as heavy bleeding or dysmenorrhea.

What are the side effects of Norethisterone Acetate, Estradiol?

Kliogest may cause a range of adverse reactions, which are generally categorized as common or serious/rare.

Common Side Effects: - Nausea - Headache - Breast tenderness - Mood changes - Irregular bleeding - Weight gain

Serious or Rare Side Effects: - Deep vein thrombosis - Pulmonary embolism - Stroke - Myocardial infarction - Severe allergic reaction (anaphylaxis) - Liver dysfunction

What precautions apply to Norethisterone Acetate, Estradiol?

Before prescribing Kliogest, clinicians should consider several safety measures.

Assess cardiovascular risk: evaluate history of thromboembolic disorders before initiating therapy. Screen for liver disease: avoid use in patients with active liver impairment. Counsel on smoking: advise smokers to quit due to increased clotting risk. Review medication history: avoid concomitant use with strong enzyme inducers. Store at ambient temperature: keep below 25°C, protect from moisture and light.

What does Norethisterone Acetate, Estradiol interact with?

Kliogest can interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Antiepileptic enzyme inducers (e.g., carbamazepine, phenytoin) may reduce contraceptive efficacy. - Rifampin: decreases hormone levels, compromising effectiveness. - Certain antiretrovirals (e.g., efavirenz) lower contraceptive efficacy. - St. John’s wort: may reduce plasma concentrations of the active hormones.

Moderate Interactions (Monitor Closely): - Antifungals (e.g., ketoconazole) may increase hormone levels. - Antibiotics (e.g., tetracycline) may affect gut flora and hormone metabolism. - SSRIs (e.g., fluoxetine) may increase bleeding risk. - Herbal supplements (e.g., ginseng) may alter hormone metabolism.

Frequently asked questions

What is Kliogest used for?+
Kliogest is a combined estrogen‑progestogen oral tablet indicated for contraception, regulation of menstrual cycles, and treatment of menstrual disorders such as heavy bleeding or dysmenorrhea in women of reproductive age. It is prescribed by a qualified healthcare professional.
How does norethisterone acetate and estradiol work?+
Norethisterone acetate is a synthetic progestogen that binds to progesterone receptors, suppressing luteinizing hormone (LH) and follicle‑stimulating hormone (FSH) release and preventing ovulation. Estradiol provides estrogenic activity, stabilising the endometrium and contributing to negative feedback on the hypothalamic‑pituitary axis, together creating an environment that prevents pregnancy.
What is the usual dose of Kliogest?+
The dosing regimen for Kliogest is determined by the prescribing clinician based on individual patient factors and local guidelines. Typically, it is taken once daily for a defined cycle, but the exact tablet strength, number of tablets per cycle, and duration must be prescribed by a qualified healthcare provider.
Is Kliogest safe to use during pregnancy or breastfeeding?+
Kliogest is contraindicated during pregnancy because it is intended to prevent conception. If pregnancy occurs, the medication should be discontinued. Limited data are available for breastfeeding; therefore, a healthcare professional should evaluate the risk‑benefit ratio before use in lactating women.
How do I order Kliogest from GNH USA?+
To request Kliogest, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Kliogest compare with other combined oral contraceptives?+
Kliogest contains norethisterone acetate and estradiol, whereas many other combined oral contraceptives use ethinyl estradiol as the estrogen component. Estradiol is a natural estrogen, which may offer a different side‑effect profile, but efficacy in preventing pregnancy is comparable when taken as directed. Choice depends on individual tolerance and physician recommendation.
What are the storage requirements for Kliogest?+
Kliogest tablets should be stored at ambient temperature, preferably below 25 °C, in the original packaging to protect them from moisture and light. Keep the medication out of reach of children and do not use if the package is damaged.
How is Kliogest administered?+
Kliogest is taken orally, usually once daily at the same time each day, with or without food, as directed by the prescriber. The tablet should be swallowed whole with water and not chewed or split unless specifically instructed.
What are the most serious risks associated with Kliogest?+
The most serious risks include thromboembolic events such as deep vein thrombosis, pulmonary embolism, stroke, and myocardial infarction, especially in women with pre‑existing risk factors. Rare cases of severe allergic reactions and liver dysfunction have also been reported. Prompt medical attention is required if symptoms of these conditions appear.
Who should not use Kliogest?+
Kliogest should not be used by women who are pregnant, have a history of thromboembolic disorders, uncontrolled hypertension, active liver disease, known or suspected breast cancer, or who are smokers over 35 years of age. It is also contraindicated in individuals with known hypersensitivity to any of its components.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Norethisterone Acetate, Estradiol
Route
Oral Use
Manufacturer
Novo Nordisk A/S
Origin
EU

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