Klikedi

Diclofenac sodium, the active ingredient in Klikedi, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as a topical gel for cutaneous use. It relieves musculoskeletal pain and inflammation in adults.

GNH USA supplies Klikedi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Diclofenac sodium is used topically to manage pain and inflammation in the musculoskeletal system.

- Musculoskeletal pain: provides localized relief of pain and swelling. - Osteoarthritis (knee): reduces joint pain and improves mobility. - Rheumatoid arthritis (hand joints): alleviates inflammation and discomfort.

Topical diclofenac may cause skin‑related reactions and, rarely, systemic adverse events.

Common Side Effects: - Skin irritation: mild burning or stinging at the application site. - Redness: localized erythema. - Itching: pruritus around the treated area. - Dry skin: occasional desquamation. - Rash: transient maculopapular eruption. - Pruritic papules: small raised lesions.

Serious or Rare Side Effects: - Allergic reactions: angioedema or anaphylaxis. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Photosensitivity: exaggerated sunburn response. - Systemic NSAID effects: gastrointestinal ulceration or bleeding. - Renal impairment: reduced kidney function with extensive use. - Hepatotoxicity: elevated liver enzymes or hepatitis.

When using topical diclofenac, consider the following safety measures.

- Pregnancy: avoid use in the third trimester due to potential fetal risk. - Breastfeeding: exercise caution; diclofenac may be excreted in milk. - Skin integrity: do not apply to broken, infected, or irritated skin. - Concomitant NSAIDs: avoid simultaneous systemic NSAID therapy to reduce additive toxicity. - Renal or hepatic impairment: use with medical supervision and monitor function. - Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Diclofenac sodium can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal and cardiovascular toxicity. - Lithium: elevated serum lithium levels.

Moderate Interactions (Monitor Closely): - Methotrexate: enhanced methotrexate toxicity. - ACE inhibitors or diuretics: possible reduction in renal function, especially in dehydrated patients.