Kliacef

Cefaclor, the active ingredient in Kliacef, is a second‑generation cephalosporin presented as an oral tablet for oral use. It is prescribed for bacterial infections such as upper respiratory tract infections, acute otitis media, sinusitis, bronchitis and uncomplicated urinary tract infections in both adults and children.

GNH USA supplies Kliacef as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution across the European Union and other global markets. The company adheres to stringent quality standards and provides regulatory support for import and export.

Cefaclor is used to treat bacterial infections affecting the respiratory and urinary tracts.

Upper respiratory tract infection: resolves bacterial pharyngitis and related symptoms. Acute otitis media: eradicates the causative organisms in middle‑ear infections. Sinusitis: clears bacterial sinus inflammation and promotes symptom relief. Bronchitis: treats acute bacterial bronchial infection and improves cough. Uncomplicated urinary tract infection: eliminates uropathogens causing cystitis.

Cefaclor may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea - Diarrhea - Abdominal pain - Rash - Headache

Serious or Rare Side Effects: - Anaphylaxis or severe allergic reactions - Clostridioides difficile‑associated colitis - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Hemolytic anemia or eosinophilic syndrome

Before prescribing cefaclor, clinicians should consider several safety precautions.

Allergy assessment: avoid in patients with known cephalosporin or penicillin hypersensitivity. Renal function: adjust dose in patients with impaired renal clearance. Gastrointestinal history: monitor for Clostridioides difficile infection in those with recent antibiotic use. Pregnancy and lactation: use only if the potential benefit outweighs the risk, as safety data are limited. Drug interactions: review concomitant medications that may affect cefaclor levels or increase bleeding risk. Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and light.

Cefaclor can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid): - Probenecid: decreases renal excretion, increasing cefaclor plasma concentrations and risk of toxicity. - Oral anticoagulants (e.g., warfarin): may enhance anticoagulant effect, raising bleeding risk.

Moderate Interactions (Monitor Closely): - Oral contraceptives: antibiotics may reduce contraceptive effectiveness; advise additional non‑hormonal methods. - Antacids containing aluminum or magnesium: may impair cefaclor absorption; separate dosing by at least 2 hours. - Diuretics (e.g., furosemide): concurrent use may increase risk of renal impairment; monitor renal function.