Klacid Uno

Clarithromycin, the active ingredient in Klacid Uno, is a macrolide antibiotic presented as a tablet for oral use. It treats bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, skin and soft‑tissue infections, and is used in Helicobacter pylori eradication regimens.

GNH USA supplies Klacid Uno as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Clarithromycin is a macrolide antibiotic used to treat infections of the respiratory, sinus, skin and gastrointestinal systems. - Community‑acquired pneumonia: eradicates causative bacteria and improves clinical recovery. - Acute bacterial sinusitis: reduces bacterial load and shortens symptom duration. - Skin and soft‑tissue infections: treats susceptible Gram‑positive and some Gram‑negative organisms. - Helicobacter pylori eradication (in combination therapy): contributes to bacterial clearance as part of triple‑therapy regimens.

Adverse reactions may occur with clarithromycin therapy.

Common Side Effects: - Nausea - Diarrhea - Abdominal pain - Taste disturbance

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) - Clostridioides difficile‑associated diarrhea - QT interval prolongation, which may lead to arrhythmia

Clarithromycin requires careful consideration of patient factors and handling. - Renal or hepatic impairment: adjust therapy based on function tests. - Cardiac risk: monitor ECG in patients with known QT prolongation. - Known macrolide hypersensitivity: avoid use. - Pregnancy category B: use only if benefit outweighs risk. - Store at below 25°C: keep in the original pack, protect from moisture.

Clarithromycin can interact with several medicines, necessitating monitoring.

Major Interactions (Avoid): - QT‑prolonging agents (e.g., cisapride, pimozide): risk of serious arrhythmia. - Statins metabolized by CYP3A4 (e.g., simvastatin, atorvastatin): increased risk of myopathy. - Ergot alkaloids (e.g., ergotamine): may cause ergotism.

Moderate Interactions (Monitor Closely): - Warfarin: enhanced anticoagulant effect, monitor INR. - Oral contraceptives: reduced efficacy, advise alternative contraception.