Klacid Uno

Clarithromycin, the active ingredient in Klacid Uno, is a macrolide antibiotic presented as an oral dosage form for oral use. It treats a range of bacterial infections, including respiratory, skin, and soft‑tissue infections, in both adult and pediatric patients as directed by a prescriber.

GNH USA supplies Klacid Uno as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Clarithromycin is used to treat bacterial infections affecting several organ systems. - Community‑acquired pneumonia: eradicates the responsible pathogens and improves respiratory symptoms. - Acute bacterial sinusitis: reduces sinus inflammation and promotes recovery. - Skin and soft‑tissue infections: eliminates causative bacteria and aids wound healing. - Helicobacter pylori eradication (as part of combination therapy): contributes to ulcer healing and infection clearance. - Pharyngitis: resolves bacterial throat infection and relieves pain.

Clarithromycin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Diarrhea: loose stools, often transient. - Abdominal pain: cramping or discomfort. - Taste disturbance: metallic or altered taste perception. - Headache: mild tension‑type headache. - Rash: mild skin erythema.

Serious or Rare Side Effects: - Hepatotoxicity: elevated liver enzymes or jaundice. - QT prolongation: cardiac rhythm disturbances. - Severe allergic reactions: anaphylaxis, angioedema. - Clostridioides difficile colitis: severe diarrhea with abdominal pain. - Hematologic abnormalities: neutropenia or thrombocytopenia. - Stevens‑Johnson syndrome: severe skin blistering.

Clarithromycin should be used with caution in certain clinical situations. - Hepatic impairment: adjust therapy and monitor liver function. - Renal impairment: consider dose adjustment in severe cases. - Cardiac risk: avoid in patients with known QT prolongation or electrolyte disturbances. - Drug‑induced photosensitivity: advise protection from excessive sunlight. - Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment. - Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and light.

Clarithromycin interacts with several medicines that affect its metabolism or cardiac safety.

Major Interactions (Avoid): - Cisapride: risk of serious cardiac arrhythmias. - Pimozide: may cause QT prolongation and ventricular tachycardia. - Ergot alkaloids: increased risk of ergotism. - Certain statins (e.g., simvastatin, lovastatin): heightened risk of myopathy.

Moderate Interactions (Monitor Closely): - Warfarin: may enhance anticoagulant effect, monitor INR. - Theophylline: increased plasma levels, watch for toxicity. - Carbamazepine: may reduce clarithromycin levels, assess efficacy. - Digoxin: potential increase in serum concentration. - Antacids containing aluminum or magnesium: may reduce absorption, separate dosing.