Klacid Sr

Clarithromycin, the active ingredient in Klacid Sr, is a macrolide antibiotic presented as an oral dosage form for systemic use. It treats a range of bacterial infections in adults and children when prescribed by a healthcare professional.

GNH USA supplies Klacid Sr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Clarithromycin is indicated for bacterial infections affecting the respiratory, sinus, skin and gastrointestinal systems.

- Community‑acquired pneumonia: effective treatment of infection caused by susceptible bacteria. - Acute bacterial sinusitis: resolves sinus inflammation due to bacterial pathogens. - Skin and soft‑tissue infections: eradicates susceptible Staphylococcus and Streptococcus species. - Helicobacter pylori eradication (in combination therapy): contributes to bacterial clearance as part of triple‑therapy regimens. - Other susceptible bacterial infections: used where the pathogen is known to be clarithromycin‑sensitive.

Clarithromycin may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Nausea - Diarrhea - Abdominal pain - Altered taste sensation - Headache - Vomiting

Serious or Rare Side Effects: - Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome) - Clostridioides difficile‑associated diarrhea - Elevated liver enzymes or hepatitis - QT interval prolongation and arrhythmias - Hepatotoxicity - Severe skin reactions

Before initiating clarithromycin therapy, consider the following safety measures.

- Assess renal function: adjust dose in severe impairment. - Monitor liver enzymes: use with caution in hepatic disease. - Avoid use in patients with known macrolide hypersensitivity. - Review concomitant medications for potential interactions. - Pregnancy and lactation: prescribe only if benefits outweigh potential risks. - Store at room temperature: keep in the original container, protect from moisture and heat.

Clarithromycin interacts with several medicines; careful review is required.

Major Interactions (Avoid): - Cisapride: risk of serious cardiac arrhythmias. - Ergot alkaloids: risk of ergotism. - Pimozide: increased plasma concentrations leading to toxicity.

Moderate Interactions (Monitor Closely): - Warfarin: enhanced anticoagulant effect; monitor INR. - Theophylline: increased serum levels; monitor for toxicity.