GNH USA

Europe — EMA

Kivizidiale

GNH USA supplies Kivizidiale (Timolol/Travoprost), a beta‑blocker and prostaglandin analog combination for primary open‑angle glaucoma and ocular

Timolol, Travoprost

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What is Timolol, Travoprost?

Timolol and Travoprost, the active ingredients in Kivizidiale, are a beta‑blocker and prostaglandin analog combination presented as eye drops for ocular use. It treats primary open‑angle glaucoma and ocular hypertension in adults.

GNH USA supplies Kivizidiale as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Timolol, Travoprost used for?

Kivizidiale is indicated for conditions involving elevated intra‑ocular pressure.

Primary open‑angle glaucoma: lowers intra‑ocular pressure to reduce the risk of optic nerve damage. Ocular hypertension: reduces intra‑ocular pressure to prevent progression to glaucoma.

What are the side effects of Timolol, Travoprost?

Kivizidiale may cause ocular and systemic adverse reactions.

Common Side Effects: - Eye irritation or burning sensation - Blurred vision after instillation - Redness of the conjunctiva - Dry eye or itching

Serious or Rare Side Effects: - Severe allergic reaction (e.g., angio‑edema) - Significant worsening of glaucoma - Systemic bradycardia or hypotension - Bronchospasm in susceptible individuals

What precautions apply to Timolol, Travoprost?

Before using Kivizidiale, consider the following safety measures.

Assess cardiovascular status: avoid in patients with severe bradycardia or heart block. Evaluate respiratory condition: use with caution in asthma or COPD. Monitor intra‑ocular pressure: ensure adequate pressure reduction after initiation. Avoid concurrent use with other beta‑blocker eye drops. Store at room temperature: keep in the original container, protect from light and moisture.

What does Timolol, Travoprost interact with?

Kivizidiale can interact with other medications; review patient medication lists.

Major Interactions (Avoid): - Systemic beta‑blockers (e.g., propranolol): may cause additive bradycardia. - Non‑selective beta‑blocker inhalers: increase risk of bronchospasm. - Other prostaglandin analog eye drops: may exacerbate ocular side effects.

Moderate Interactions (Monitor Closely): - Carbonic anhydrase inhibitor eye drops (e.g., dorzolamide): may produce excessive IOP lowering. - Topical corticosteroids: can diminish the IOP‑lowering effect. - Antihistamine eye drops: may increase ocular irritation.

Frequently asked questions

What is Kivizidiale used for?+
Kivizidiale is an ophthalmic eye‑drop formulation that combines timolol and travoprost to lower intra‑ocular pressure. It is prescribed for adults with primary open‑angle glaucoma or ocular hypertension to help prevent optic nerve damage and preserve visual field.
How does timolol and travoprost work together?+
Timolol, a non‑selective beta‑blocker, decreases the production of aqueous humour by blocking β‑adrenergic receptors in the ciliary body. Travoprost, a prostaglandin F2α analogue, enhances uveoscleral outflow of aqueous humour. The dual mechanism provides a complementary reduction in intra‑ocular pressure.
What is the usual dose of Kivizidiale?+
The dosing regimen for Kivizidiale is determined by the prescribing ophthalmologist. Typically, one drop is instilled in the affected eye(s) once daily in the evening, but the exact dose and timing should follow the clinician’s instructions.
Is Kivizidiale safe during pregnancy or breastfeeding?+
The safety of Kivizidiale in pregnancy or while breastfeeding has not been fully established. Healthcare providers should weigh the potential benefits against possible risks and consider alternative treatments if appropriate.
How do I order Kivizidiale from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Kivizidiale compare with other glaucoma eye drops?+
Compared with single‑component agents, Kivizidiale offers a combined mechanism—reduced aqueous production and increased outflow—potentially achieving greater intra‑ocular pressure reduction. This may reduce the need for multiple separate drops, improving adherence, but individual response varies and should be assessed by the ophthalmologist.
What are the storage and handling requirements for Kivizidiale?+
Kivizidiale should be stored at room temperature, below 25 °C, in its original packaging. Keep the bottle tightly closed, protect it from light and moisture, and discard any solution that appears discolored or contains particles.
How is Kivizidiale administered?+
Kivizidiale is applied as an eye drop. The patient should wash hands, tilt the head back, pull down the lower eyelid to form a pocket, and instill one drop into the conjunctival sac of the prescribed eye(s). Close the eye gently for a few seconds without blinking excessively.
What are the most serious risks associated with Kivizidiale?+
Serious risks include severe allergic reactions, marked worsening of glaucoma, systemic bradycardia or hypotension, and bronchospasm, especially in patients with pre‑existing respiratory disease. Any sudden vision changes, chest discomfort, or breathing difficulties should prompt immediate medical attention.
Who should not use Kivizidiale?+
Kivizidiale is contraindicated in patients with known hypersensitivity to timolol, travoprost, or any excipients in the formulation. It should also be avoided in individuals with severe sinus bradycardia, second‑ or third‑degree heart block, uncontrolled asthma, or active ocular infections without prior medical clearance.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Timolol, Travoprost
Route
Ocular Use
Manufacturer
Laboratoire Chauvin
Origin
EU

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