GNH USA

Europe — EMA

Kivizidiale

GNH USA supplies Kivizidiale (Timolol/Travoprost), a beta blocker/prostaglandin analog for primary open‑angle glaucoma and ocular hypertension.

Timolol, Travoprost

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What is Timolol, Travoprost?

Timolol/Travoprost, the active ingredient in Kivizidiale, is a beta blocker/prostaglandin analog presented as eye drops for ocular use. It lowers intra‑ocular pressure and is prescribed for patients with primary open‑angle glaucoma or ocular hypertension. GNH USA supplies Kivizidiale as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Timolol, Travoprost used for?

Kivizidiale is used in the management of ocular conditions where reduction of intra‑ocular pressure is required. - Primary open‑angle glaucoma: lowers intra‑ocular pressure to slow optic nerve damage. - Ocular hypertension: reduces pressure to prevent progression to glaucoma. - Post‑operative ocular hypertension: helps control pressure spikes after eye surgery.

What are the side effects of Timolol, Travoprost?

Kivizidiale may cause ocular and systemic reactions.

Common Side Effects: - Eye irritation or burning sensation. - Blurred vision shortly after instillation. - Conjunctival hyperemia (red eye). - Dry eye or foreign‑body sensation. - Transient headache. - Mild eyelid edema.

Serious or Rare Side Effects: - Severe allergic reaction with swelling or rash. - Worsening of glaucoma or sudden pressure increase. - Systemic bradycardia or hypotension. - Respiratory distress in asthmatic patients. - Chest pain or myocardial ischemia. - Ocular infection or corneal ulceration.

What precautions apply to Timolol, Travoprost?

Before prescribing Kivizidiale, clinicians should consider patient‑specific factors and monitor for adverse events. - Cardiovascular assessment: evaluate for bradycardia or heart block. - Respiratory status: avoid in patients with severe asthma or COPD. - Pregnancy and lactation: use only if benefits outweigh risks. - Concomitant beta‑blocker therapy: monitor for additive systemic effects. - Contact lens wearers: remove lenses before instillation and wait before reinserting. - Store at room temperature: keep in original container, protect from moisture and direct light.

What does Timolol, Travoprost interact with?

Kivizidiale can interact with other medicines that affect ocular pressure or systemic beta‑adrenergic activity.

Major Interactions (Avoid): - Systemic non‑selective beta‑blockers: may cause excessive bradycardia or hypotension. - Other ocular beta‑blocker drops: risk of additive ocular hypotensive effect. - Sympathomimetic agents (e.g., epinephrine eye drops): may reduce efficacy.

Moderate Interactions (Monitor Closely):\n- Carbonic anhydrase inhibitor eye drops: may enhance intra‑ocular pressure reduction. - Anticholinergic ophthalmic agents: monitor for pupil changes. - NSAID eye drops: watch for increased ocular irritation.

Frequently asked questions

What conditions is Kivizidiale used to treat?+
Kivizidiale is indicated for the reduction of elevated intra‑ocular pressure in patients with primary open‑angle glaucoma and ocular hypertension. It may also be used to manage post‑operative pressure spikes after eye surgery, helping to prevent optic nerve damage.
How does the combination of Timolol and Travoprost work?+
Timolol, a non‑selective beta‑adrenergic blocker, reduces the production of aqueous humor by the ciliary body. Travoprost, a prostaglandin F2α analogue, increases uveoscleral outflow of fluid. Together they lower intra‑ocular pressure through complementary mechanisms affecting both fluid production and drainage.
What is the usual dose of Kivizidiale?+
The dosing regimen for Kivizidiale is determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Typically, one drop is instilled in the affected eye(s) once daily, but the exact schedule should follow the prescriber’s instructions.
Is Kivizidiale safe to use during pregnancy or breastfeeding?+
Safety data for Kivizidiale in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.
How do I order Kivizidiale from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity of Kivizidiale. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Kivizidiale compare with other glaucoma eye drops?+
Kivizidiale combines a beta‑blocker (Timolol) and a prostaglandin analogue (Travoprost) in a single formulation, offering dual‑mechanism pressure reduction. Compared with single‑agent drops, it may provide greater IOP lowering with fewer administrations, but individual response and tolerance vary, so clinicians choose based on patient profile.
What are the recommended storage conditions for Kivizidiale?+
Kivizidiale should be stored at room temperature, below 25 °C, in its original packaging. Keep the bottle tightly closed, protect it from moisture and direct sunlight, and discard any product that appears discolored or contains particles.
How is Kivizidiale administered?+
Kivizidiale is administered as an ocular solution. The patient should wash their hands, tilt the head back, pull down the lower eyelid, and place one drop into the conjunctival sac of the prescribed eye(s). Close the eye gently for a few minutes and avoid blinking excessively.
What are the most serious risks associated with Kivizidiale?+
Serious risks include severe allergic reactions, marked reduction in intra‑ocular pressure leading to hypotony, systemic bradycardia or hypotension, and exacerbation of asthma or chronic obstructive pulmonary disease. Patients should seek immediate medical attention if they experience chest pain, difficulty breathing, or sudden vision changes.
Who should not use Kivizidiale?+
Kivizidiale is contraindicated in patients with known hypersensitivity to Timolol, Travoprost, or any excipients in the formulation. It should also be avoided in individuals with severe sinus bradycardia, second‑ or third‑degree atrioventricular block, uncompensated heart failure, or uncontrolled asthma.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Timolol, Travoprost
Route
Ocular Use
Manufacturer
Bausch + Lomb Ireland Limited
Origin
EU

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