GNH USA

Europe — EMA

Kivizidiale

GNH USA supplies Kivizidiale (Timolol / Travoprost), a beta‑blocker and prostaglandin analog for primary open‑angle glaucoma and ocular hypertension.

Timolol, Travoprost

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What is Timolol, Travoprost?

Timolol and Travoprost, the active ingredients in Kivizidiale, are a beta‑blocker and a prostaglandin analog presented as eye drops for ocular use. The combination lowers intra‑ocular pressure and is indicated for primary open‑angle glaucoma and ocular hypertension in adult patients.\n\nGNH India supplies Kivizidiale as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Timolol, Travoprost used for?

Kivizidiale combines a beta‑blocker and a prostaglandin analog to lower intra‑ocular pressure in glaucoma‑related conditions.\n\n- Primary open‑angle glaucoma: reduces intra‑ocular pressure to slow optic nerve damage.\n- Ocular hypertension: lowers eye pressure to prevent progression to glaucoma.\n- Secondary open‑angle glaucoma: helps control pressure when other treatments are insufficient.

What are the side effects of Timolol, Travoprost?

Kivizidiale may cause ocular and systemic adverse reactions.\n\nCommon Side Effects:\n- Eye irritation or burning sensation\n- Blurred vision\n- Redness of the eye\n- Dry eye or foreign‑body sensation\n- Itching or mild eyelid swelling\n- Temporary changes in eye color (increased brown pigmentation)\n\nSerious or Rare Side Effects:\n- Severe allergic reaction (rash, swelling, difficulty breathing)\n- Worsening of glaucoma or sudden rise in intra‑ocular pressure\n- Chest pain, bradycardia, or systemic hypotension\n- Respiratory distress in asthmatic patients\n- Persistent eye pain or vision loss\n- Corneal ulceration or infection

What precautions apply to Timolol, Travoprost?

Before prescribing Kivizidiale, clinicians should consider patient‑specific factors and monitor for adverse events.\n\n- Cardiovascular assessment: beta‑blocker component may cause bradycardia or hypotension.\n- Respiratory status: avoid in patients with asthma or severe chronic obstructive pulmonary disease.\n- Intra‑ocular pressure monitoring: adjust therapy based on regular pressure measurements.\n- Concomitant ocular beta‑blockers: avoid duplicate therapy to reduce systemic exposure.\n- Pregnancy and lactation: use only if potential benefit justifies potential risk to the fetus or infant.\n- Store at room temperature: keep in the original container, protect from light and moisture.

What does Timolol, Travoprost interact with?

Kivizidiale can interact with systemic and ocular medications; awareness of potential interactions helps ensure safety.\n\nMajor Interactions (Avoid):\n- Systemic beta‑blockers (e.g., metoprolol): additive bradycardia or hypotension.\n- Other prostaglandin analog eye drops: increased risk of ocular irritation and hyperpigmentation.\n- Monoamine oxidase inhibitors: possible cardiovascular effects when combined with beta‑blocker.\n\nModerate Interactions (Monitor Closely):\n- Anticholinergic eye drops: may reduce the IOP‑lowering efficacy of timolol.\n- Topical corticosteroids: can diminish overall pressure‑lowering effect.\n- Non‑steroidal anti‑inflammatory eye drops: may increase ocular irritation when used together.

Frequently asked questions

What is Kivizidiale used for?+
Kivizidiale is a prescription eye‑drop formulation that combines timolol and travoprost to lower intra‑ocular pressure. It is indicated for the management of primary open‑angle glaucoma, secondary open‑angle glaucoma, and ocular hypertension in adult patients.
How do timolol and travoprost work together?+
Timolol reduces the production of aqueous humor by blocking β‑adrenergic receptors in the ciliary body, while travoprost increases uveoscleral outflow by activating prostaglandin F2α receptors. The complementary mechanisms result in a greater overall reduction of intra‑ocular pressure than either agent alone.
What is the usual dose of Kivizidiale?+
The dosing regimen for Kivizidiale is determined by the prescribing clinician. Typically, one drop is instilled in the affected eye(s) once daily, but the exact frequency and duration depend on the individual patient's response and clinical judgment.
Is Kivizidiale safe during pregnancy or breastfeeding?+
Safety data for timolol and travoprost in pregnancy and lactation are limited. The product should be used only if the potential therapeutic benefit justifies any possible risk to the fetus or nursing infant, and this decision must be made by the treating physician.
How do I order Kivizidiale from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.
How does Kivizidiale compare with other glaucoma eye drops?+
Compared with single‑agent drops, Kivizidiale offers a dual mechanism—decreasing aqueous humor production and increasing outflow—providing stronger intra‑ocular pressure control. This can reduce the need for multiple separate medications, potentially improving adherence while maintaining a safety profile similar to its individual components.
How should Kivizidiale be stored and handled?+
Store Kivizidiale at room temperature, below 25 °C, in the original packaging. Protect the bottle from direct sunlight, moisture and extreme temperatures. Keep the dropper tip clean and avoid contaminating the solution.
How is Kivizidiale administered?+
Kivizidiale is applied as an ocular solution. The patient should wash their hands, tilt the head back, pull down the lower eyelid, and place one drop into the conjunctival sac of each prescribed eye. Close the eye gently for a few seconds and avoid blinking excessively.
What are the most serious risks associated with Kivizidiale?+
Serious risks include severe allergic reactions (e.g., rash, swelling, breathing difficulty), a sudden increase in intra‑ocular pressure, systemic cardiovascular effects such as bradycardia, hypotension or chest pain, and respiratory distress in patients with asthma. Immediate medical attention is required if any of these occur.
Who should not use Kivizidiale?+
Kivizidiale is contraindicated in patients with known hypersensitivity to timolol, travoprost, or any excipients, as well as in individuals with severe asthma, chronic obstructive pulmonary disease, sinus bradycardia, or advanced heart block. It should also be avoided in patients with active ocular infections or inflammation.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Timolol, Travoprost
Route
Ocular Use
Manufacturer
Bausch + Lomb Ireland Limited
Origin
EU

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