Ketoprofen Rompharm

Ketoprofen, the active ingredient in Ketoprofen Rompharm, is a nonsteroidal anti-inflammatory drug presented as an injectable solution for intramuscular and intravenous use. It treats mild to moderate pain, postoperative pain, musculoskeletal inflammation, rheumatoid arthritis and osteoarthritis in adult patients.

GNH USA supplies Ketoprofen Rompharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

- Mild to moderate pain: provides analgesic relief by decreasing prostaglandin‑mediated nociception. - Post‑operative pain: helps control surgical pain during the immediate recovery period. - Musculoskeletal pain and inflammation: reduces swelling and discomfort in conditions such as sprains or tendonitis. - Rheumatoid arthritis and osteoarthritis: alleviates joint inflammation and improves mobility in chronic arthritic conditions.

Ketoprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Injection site reactions: erythema, swelling or pain.

Serious or Rare Side Effects: - Severe gastrointestinal bleeding or ulceration. - Renal impairment: reduced kidney function or acute failure. - Hypersensitivity reactions: anaphylaxis, skin rash or Stevens‑Johnson syndrome.

Ketoprofen requires careful use in several clinical situations.

- Renal function: monitor patients with pre‑existing kidney disease. - Cardiovascular risk: use cautiously in patients with hypertension or heart disease. - Gastrointestinal history: avoid in individuals with peptic ulcer disease or bleeding. - Concomitant NSAIDs or anticoagulants: increase risk of bleeding. - Pregnancy and lactation: safety not established; avoid unless clearly needed. - Store at ambient temperature: keep in original container, protect from light and moisture.

Ketoprofen can interact with several drug classes, influencing safety and efficacy.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened bleeding risk. - Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity. - Corticosteroids: increased risk of ulceration and bleeding.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce renal perfusion; monitor kidney function. - Diuretics (especially thiazides): may enhance nephrotoxic potential. - Lithium: NSAIDs can raise serum lithium levels.