Ketonal

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug presented as a suppository for rectal use. It treats mild to moderate pain, inflammatory musculoskeletal conditions such as rheumatoid arthritis and osteoarthritis, postoperative pain, and dysmenorrhea in adult patients.

GNH USA supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier, providing reliable logistics, quality assurance and regulatory support to hospitals, pharmacies and clinics worldwide. Our global network ensures timely delivery and compliance with local import requirements, while maintaining product integrity throughout the supply chain.

Ketoprofen acts as an NSAID to reduce inflammation and pain in several musculoskeletal and postoperative conditions.

Mild to moderate pain: provides analgesic relief for acute or chronic pain conditions. Inflammatory musculoskeletal conditions: reduces inflammation and improves function in rheumatoid arthritis and osteoarthritis. Post‑operative pain: alleviates pain following surgical procedures. Dysmenorrhea: lessens menstrual cramps and associated discomfort.

Ketonal may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea, dyspepsia or abdominal discomfort. - Headache or dizziness. - Skin rash or itching.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Acute renal impairment or failure. - Severe hypersensitivity reactions such as Stevens‑Johnson syndrome or anaphylaxis.

When prescribing Ketonal, several precautionary measures should be observed to minimize risk.

- Assess gastrointestinal risk: evaluate history of ulcers or bleeding before use. - Monitor renal function: check creatinine clearance in patients with kidney disease. - Use lowest effective dose: limit duration to the shortest period necessary. - Avoid in known hypersensitivity: discontinue if allergic reactions occur. - Caution in cardiovascular disease: consider alternative therapy in patients with heart failure or ischemic disease. - Store at room temperature: keep in the original package, protect from moisture and heat.

Ketonal can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Other NSAIDs or aspirin: heightened gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding tendency.

Moderate Interactions (Monitor Closely): - ACE inhibitors or diuretics: may reduce renal function. - Lithium: NSAIDs can increase lithium serum levels. - Methotrexate: reduced clearance leading to toxicity.