Ketonal

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug presented as a suppository for rectal use. It treats mild to moderate pain and inflammatory conditions such as arthritis in adults.

GNH USA supplies Ketonal as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketonal (ketoprofen) is an NSAID that reduces inflammation and pain in several musculoskeletal and arthritic conditions.

- Mild to moderate pain: Provides analgesic relief for acute or chronic pain episodes. - Osteoarthritis and rheumatoid arthritis: Decreases joint inflammation and improves mobility. - Musculoskeletal injuries: Reduces swelling and discomfort associated with sprains, strains, and overuse injuries.

Ketonal may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain. - Headache or dizziness. - Local irritation at the rectal site. - Mild skin rash or itching. - Transient elevation of liver enzymes.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration. - Severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. - Renal impairment or acute kidney injury. - Cardiovascular events including myocardial infarction or stroke. - Hepatotoxicity with marked liver enzyme elevation.

Before using Ketonal, consider the following safety measures.

- Assess gastrointestinal risk: avoid in patients with a history of ulcers or bleeding. - Evaluate renal function: use cautiously in those with impaired kidney function. - Monitor cardiovascular status: patients with heart disease should be observed closely. - Check for hypersensitivity: discontinue if signs of allergic reaction appear. - Avoid concurrent use with other NSAIDs or anticoagulants unless medically justified. - Store below 25°C: keep in the original packaging, protect from moisture.

Ketonal can interact with several medication classes; awareness helps prevent adverse events.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Selective COX‑2 inhibitors: additive gastrointestinal toxicity. - High‑dose aspirin: heightened ulcer risk.

Moderate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs: may reduce renal perfusion, monitor kidney function. - Diuretics: possible decrease in renal clearance of ketoprofen. - Lithium: NSAIDs can raise lithium levels, requiring serum monitoring.