Ketonal

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It treats mild to moderate pain and inflammatory conditions such as rheumatoid arthritis, osteoarthritis and other musculoskeletal disorders.

GNH USA supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketonal, a nonsteroidal anti-inflammatory drug, is used to manage pain and inflammation in several musculoskeletal and rheumatic conditions.

- Mild to moderate pain: provides analgesic relief for everyday aches and postoperative discomfort. - Rheumatoid arthritis: reduces joint inflammation and swelling, improving mobility. - Osteoarthritis: alleviates chronic joint pain and stiffness associated with degenerative changes. - Musculoskeletal pain: eases strain, sprain and tendonitis symptoms.

Ketonal may cause a range of adverse reactions, most of which are related to its NSAID class.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin reactions: rash or pruritus. - Elevated liver enzymes: transient laboratory changes.

Serious or Rare Side Effects: - Peptic ulcer disease or gastrointestinal bleeding. - Renal impairment: reduced kidney function or acute failure. - Cardiovascular events: increased risk of myocardial infarction or stroke. - Severe hypersensitivity: anaphylaxis, angioedema or Stevens‑Johnson syndrome. - Hepatotoxicity: clinically significant liver injury.

Before prescribing Ketonal, clinicians should consider several safety aspects.

- Known hypersensitivity: avoid in patients with previous allergic reactions to ketoprofen or other NSAIDs. - Gastrointestinal risk: use cautiously in individuals with a history of ulcers or bleeding. - Renal function: monitor kidney parameters in patients with existing renal disease. - Cardiovascular disease: assess risk in patients with hypertension, heart failure or prior thrombotic events. - Pregnancy and lactation: evaluate benefit‑risk ratio; generally avoid unless clearly indicated. - Store at room temperature below 25°C: keep in the original pack, protect from moisture.

Ketonal can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or aspirin: heightened gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): elevated hemorrhage potential. - ACE inhibitors or diuretics: possible reduction in renal perfusion.

Moderate Interactions (Monitor Closely): - Lithium: NSAIDs may raise lithium serum levels. - Methotrexate: reduced clearance leading to toxicity. - Corticosteroids: additive risk of ulceration. - Cyclosporine: increased nephrotoxicity. - Antihypertensives: possible attenuation of blood‑pressure‑lowering effect.