Ketonal

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable solution for intramuscular and intravenous use. It treats mild to moderate pain, post‑operative pain, musculoskeletal pain, rheumatoid arthritis and osteoarthritis in adult patients.

GNH USA supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketonal (ketoprofen) is an NSAID that reduces inflammation and pain in several musculoskeletal and postoperative conditions.

- Mild to moderate pain: provides analgesia for acute pain episodes. - Post‑operative pain: helps control discomfort after surgical procedures. - Rheumatoid arthritis: reduces joint inflammation and pain. - Osteoarthritis: alleviates chronic joint discomfort. - Musculoskeletal pain: eases strain‑related soreness and stiffness.

Ketonal may cause a range of adverse reactions, from mild to severe. Awareness of these effects helps clinicians monitor patients appropriately.

Common Side Effects: - Nausea or dyspepsia. - Headache. - Dizziness. - Injection‑site pain or erythema. - Diarrhoea.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Acute renal failure. - Hepatic dysfunction. - Anaphylactic reactions. - Thrombotic cardiovascular events.

Ketonal should be used with caution in patients with specific risk factors and comorbidities.

- Renal function: monitor kidney parameters in patients with pre‑existing renal disease. - Gastrointestinal risk: avoid in individuals with active peptic ulcer disease or a history of serious GI bleeding. - Cardiovascular health: use cautiously in patients with established heart disease or hypertension. - Pregnancy and lactation: avoid unless clearly indicated and benefits outweigh risks. - Concomitant drugs: review use of other NSAIDs, anticoagulants or corticosteroids for additive toxicity. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Ketonal can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Other NSAIDs: additive gastrointestinal toxicity. - Corticosteroids: heightened ulcer risk.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce renal function. - Diuretics: potential for renal impairment. - Lithium: ketoprofen may raise serum lithium levels.