Ketonal

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a sterile injectable for intramuscular and intravenous use. It is employed to relieve mild to moderate pain, post‑operative discomfort, musculoskeletal pain, rheumatoid arthritis and osteoarthritis in adult patients.

GNH USA supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketonal is indicated for conditions involving inflammation and pain, acting through cyclo‑oxygenase inhibition. - Mild to moderate pain: provides analgesia for everyday pain such as dental or headache. - Post‑operative pain: reduces pain and inflammation after surgical procedures. - Musculoskeletal pain: alleviates strain‑related discomfort in muscles and joints. - Rheumatoid arthritis: helps control inflammatory joint pain and swelling. - Osteoarthritis: improves joint function and reduces chronic pain.

Ketonal may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia, or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin rash or pruritus. - Injection site pain or erythema.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration. - Acute renal impairment or failure. - Severe skin reactions such as Stevens‑Johnson syndrome. - Anaphylactic or anaphylactoid reactions. - Hepatotoxicity with elevated liver enzymes.

Before using Ketonal, consider the following safety measures. - Cardiovascular risk: avoid in patients with established heart disease unless benefits outweigh risks. - Gastrointestinal history: use cautiously in those with prior ulcers or bleeding. - Renal function: monitor kidney parameters in patients with chronic kidney disease. - Concomitant NSAIDs or anticoagulants: increase risk of bleeding; assess necessity. - Pregnancy and lactation: only use if clearly indicated after professional evaluation. - Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture and direct sunlight.

Ketonal can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened risk of serious bleeding. - High‑dose aspirin or other NSAIDs: additive gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): increased bleeding tendency.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce renal function, especially in dehydrated patients. - Diuretics: potential for reduced renal perfusion. - Lithium: NSAIDs can raise lithium serum levels, requiring monitoring.