Ketonal

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable solution for intramuscular and intravenous use. It is employed to relieve mild to moderate pain and to reduce inflammation in conditions such as rheumatoid arthritis, osteoarthritis, postoperative pain, and other musculoskeletal disorders in adult patients.

GNH USA supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑assured products for diverse healthcare settings and patient care teams through reliable logistics.

Ketoprofen is used in the management of inflammatory and pain conditions by inhibiting prostaglandin synthesis. - Rheumatoid arthritis: reduces joint inflammation and pain, improving mobility and functional ability. - Osteoarthritis: alleviates chronic joint discomfort and stiffness, supporting daily activities. - Post‑operative pain: provides effective analgesia following surgical procedures to enhance recovery. - Musculoskeletal pain: relieves strain‑related aches and soreness in muscles, tendons, and ligaments. - Acute mild to moderate pain: controls pain from injuries, dental procedures, or other short‑term sources.

Ketoprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort. - Headache: mild to moderate intensity. - Dizziness or vertigo: transient balance disturbances. - Injection‑site reactions: pain, erythema, or swelling at the administration site.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration: potentially life‑threatening hemorrhage. - Renal impairment: acute kidney injury or reduced renal function. - Hepatic dysfunction: elevated liver enzymes or hepatitis. - Severe hypersensitivity: Stevens‑Johnson syndrome, toxic epidermal necrolysis, or anaphylaxis.

When using Ketoprofen, clinicians should evaluate patient risk factors and monitor for complications. - Assess renal function: adjust use in patients with existing kidney disease. - Monitor hepatic enzymes: avoid in severe liver impairment. - Check for NSAID hypersensitivity: discontinue if allergic reactions occur. - Use cautiously in the elderly: higher incidence of gastrointestinal bleeding. - Avoid concurrent anticoagulants unless necessary: increased risk of bleeding. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Ketoprofen can interact with several medicines, altering efficacy or safety, and should be reviewed before co‑administration.

Major Interactions (Avoid): - Other NSAIDs or aspirin: additive gastrointestinal toxicity. - Anticoagulants (warfarin, DOACs): heightened bleeding risk. - Corticosteroids: increased ulceration and gastrointestinal complications.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in renal function. - Diuretics: risk of renal impairment when combined. - Lithium: ketoprofen may raise serum lithium concentrations.