Ketonal

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug presented as an injection for intramuscular and intravenous use. It treats pain and inflammation associated with conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal disorders, and postoperative recovery, and is prescribed for adult patients requiring rapid analgesic effect.

GNH USA supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketonal (ketoprofen) is used to manage pain and inflammation across several musculoskeletal and postoperative conditions.

- Rheumatoid arthritis: reduces joint pain, swelling and stiffness. - Osteoarthritis: alleviates chronic joint discomfort and improves mobility. - Musculoskeletal pain: provides rapid relief of strain, sprain and back pain. - Postoperative pain: controls acute pain following surgical procedures. - General inflammatory conditions: diminishes swelling and erythema in acute inflammatory episodes.

Ketonal may cause a range of adverse reactions, from mild to severe. Awareness of these effects helps clinicians monitor patients appropriately.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Injection site reactions: erythema, swelling or pain. - Transient elevation of liver enzymes. - Mild renal function changes.

Serious or Rare Side Effects: - Severe gastrointestinal bleeding or ulceration. - Acute renal failure or significant creatinine rise. - Anaphylactic or severe hypersensitivity reactions. - Cardiovascular events such as myocardial infarction or stroke. - Hepatotoxicity with marked transaminase elevation. - Blood dyscrasias including thrombocytopenia.

When prescribing Ketonal, clinicians should consider several safety aspects to minimise risk.

- Renal function: assess baseline kidney status and monitor during therapy. - Gastrointestinal risk: avoid in patients with active ulcers or a history of serious GI bleeding. - Cardiovascular health: use cautiously in uncontrolled hypertension or known cardiovascular disease. - Bleeding tendency: evaluate before surgery or in patients on anticoagulants. - Drug interactions: review concomitant medications for potential additive toxicity. - Store below 25°C: keep in the original container, protect from light and moisture.

Ketonal can interact with various medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened risk of serious bleeding. - Selective COX‑2 inhibitors: additive renal and gastrointestinal toxicity. - Lithium: increased serum lithium concentrations leading to toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in renal function. - Loop or thiazide diuretics: enhanced nephrotoxic potential. - Methotrexate: reduced clearance and possible toxicity.