Ketonal

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug presented as an injectable solution for intramuscular, intravenous use. It treats pain and inflammation in adult patients with musculoskeletal and arthritic conditions.

GNH USA supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen acts as an NSAID to relieve pain and inflammation in several musculoskeletal and rheumatic disorders. - Rheumatoid arthritis: reduces joint swelling, pain and stiffness. - Osteoarthritis: alleviates chronic joint pain and improves mobility. - Acute musculoskeletal pain: provides rapid relief after injury or strain. - Post‑operative pain: helps control pain following surgical procedures.

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Gastrointestinal discomfort such as nausea or dyspepsia. - Headache or dizziness. - Mild skin rash or itching. - Elevated blood pressure. - Transient renal function changes.

Serious or Rare Side Effects: - Peptic ulcer perforation or gastrointestinal bleeding. - Severe hypersensitivity reactions including anaphylaxis. - Hepatotoxicity with jaundice. - Thrombotic events such as myocardial infarction or stroke. - Severe renal impairment or acute kidney injury.

Ketoprofen requires careful use in several clinical situations. - Renal impairment: monitor kidney function and adjust therapy. - Cardiovascular risk: avoid in patients with recent myocardial infarction or uncontrolled hypertension. - Gastrointestinal history: use gastro‑protective agents if ulcer disease is present. - Pregnancy and lactation: assess risk‑benefit; generally avoid in the third trimester. - Concomitant anticoagulants: increase bleeding risk; monitor coagulation parameters. - Store below 25°C: keep in original container, protect from light and moisture.

Ketoprofen can interact with several drug classes, requiring vigilance.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened bleeding risk. - Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity. - High‑dose aspirin: increased renal and gastric adverse effects.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function. - Diuretics: may impair renal perfusion. - Selective serotonin reuptake inhibitors (SSRIs): modest increase in bleeding tendency.