Ketonal

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a topical formulation for external use. It is used to relieve pain and reduce inflammation in musculoskeletal tissues, particularly in adults with acute or chronic conditions.

GNH USA supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketonal (ketoprofen) acts on inflammatory pathways of the musculoskeletal system, providing analgesic and anti‑inflammatory effects. - Osteoarthritis: reduces joint pain and swelling, improving mobility. - Rheumatoid arthritis: alleviates chronic joint inflammation and discomfort. - Musculoskeletal injuries: provides symptomatic relief of pain, bruising and localized inflammation.

Ketonal may cause a range of skin‑related and systemic reactions.

Common Side Effects: - Local skin irritation: redness, itching, or burning at the application site. - Dryness or peeling of the skin. - Mild headache. - Gastro‑intestinal discomfort when absorbed systemically. - Dizziness.

Serious or Rare Side Effects: - Severe allergic reactions: rash, swelling, or anaphylaxis. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hepatotoxicity: elevated liver enzymes or jaundice. - Renal impairment: reduced kidney function or acute failure. - Gastro‑intestinal ulceration or bleeding. - Cardiovascular events: increased risk of heart attack or stroke.

When considering Ketonal, several safety measures should be observed. - Assess renal function: avoid or adjust use in patients with significant kidney disease. - Monitor hepatic function: contraindicated in severe liver impairment. - Avoid in known NSAID hypersensitivity: discontinue immediately if reactions occur. - Use the lowest effective dose: limit duration to reduce gastrointestinal risk. - Store at room temperature: keep in the original container, protect from moisture and light.

Ketonal can interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Selective COX‑2 inhibitors: additive gastrointestinal toxicity. - Lithium: potential rise in serum lithium concentrations.

Moderate Interactions (Monitor Closely): - ACE inhibitors: possible reduction in renal function. - Diuretics: heightened risk of renal impairment. - Methotrexate: decreased clearance leading to toxicity.