Ketonal Duo

Ketoprofen, the active ingredient in Ketonal Duo, is a nonsteroidal anti-inflammatory drug presented as an oral tablet for oral use. It is used to relieve pain, reduce inflammation, and manage symptoms of arthritis in adults. GNH USA supplies Ketonal Duo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen acts on inflammatory pathways and is indicated for several painful and inflammatory conditions. - Pain: provides analgesic relief for mild to moderate acute pain. - Inflammation: reduces swelling and redness associated with inflammatory processes. - Arthritis: helps control joint pain and stiffness in osteoarthritis and rheumatoid arthritis.

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin rash or mild itching. - Elevated blood pressure. - Mild renal function changes.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe liver injury or hepatitis. - Acute kidney injury or renal failure. - Anaphylactic or severe allergic reactions. - Cardiovascular events such as myocardial infarction. - Blood dyscrasias like thrombocytopenia.

Ketoprofen should be used with caution in specific clinical situations. - Cardiovascular risk: avoid in patients with uncontrolled hypertension or recent heart disease. - Gastrointestinal safety: assess history of ulcers or bleeding before use. - Renal function: monitor kidney parameters in patients with existing renal impairment. - Hepatic health: avoid in severe liver disease and monitor liver enzymes. - Pregnancy and lactation: consult a healthcare professional before use. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Ketoprofen can interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding potential.

Moderate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs: may reduce renal perfusion, especially in volume‑depleted patients. - Diuretics: potential for reduced antihypertensive effect. - Lithium: NSAIDs can raise lithium serum levels, risking toxicity.