Ketonal Active

Ketoprofen, the active ingredient in Ketonal Active, is a nonsteroidal anti‑inflammatory drug presented as an oral dosage form for systemic use. It is employed to relieve pain and reduce inflammation in conditions such as arthritis and musculoskeletal disorders.

GNH USA supplies Ketonal Active as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen acts on inflammatory pathways and is indicated for several painful and inflammatory conditions.

Rheumatoid arthritis: reduces joint pain, swelling and stiffness. Osteoarthritis: alleviates chronic joint discomfort and improves mobility. Musculoskeletal pain: provides relief for strains, sprains and back pain. Post‑operative pain: helps control acute pain after surgical procedures.

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Gastrointestinal discomfort such as nausea or dyspepsia. - Headache or dizziness. - Mild skin rash or itching. - Elevated blood pressure. - Fluid retention or mild edema.

Serious or Rare Side Effects: - Peptic ulcer disease or gastrointestinal bleeding. - Severe hypersensitivity reactions, including anaphylaxis. - Hepatotoxicity or elevated liver enzymes. - Renal impairment or acute kidney injury. - Cardiovascular events such as myocardial infarction or stroke.

When using Ketoprofen, consider the following safety measures.

Avoid use in patients with active peptic ulcer disease: risk of gastrointestinal bleeding. Monitor renal function in individuals with pre‑existing kidney disease. Assess cardiovascular risk in patients with hypertension or heart disease. Use caution in elderly patients: higher susceptibility to adverse effects. Avoid concurrent use with other NSAIDs or anticoagulants unless medically justified. Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Ketoprofen can interact with several drug classes, requiring attention to avoid harmful effects.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding. - ACE inhibitors or diuretics: potential reduction in renal function. - Lithium: increased lithium serum concentrations. - Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely): - Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity. - Corticosteroids: increased ulcer risk. - Diabetic medications: possible alteration of blood glucose control. - Antihypertensives: may diminish antihypertensive effect. - Oral hypoglycemics: potential for reduced efficacy.