Ketoconazol Cf

Ketoconazole, the active ingredient in Ketoconazol Cf, is an azole antifungal presented as a topical formulation for skin use. It is applied to treat fungal infections of the skin and scalp in adults and children when appropriate.

GNH USA supplies Ketoconazol Cf as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoconazole is an azole antifungal used to treat superficial fungal infections of the skin and scalp. - Tinea corporis (ringworm of the body): reduces fungal growth and clears lesions. - Tinea cruris (jock itch): alleviates itching and eliminates the causative dermatophytes. - Tinea pedis (athlete’s foot): eradicates the infection and prevents recurrence. - Seborrheic dermatitis: controls Malassezia overgrowth and reduces scaling. - Pityriasis versicolor: clears pigmentary changes by inhibiting yeast proliferation. - Candidal skin infections: treats localized Candida overgrowth on the skin.

Ketoconazole may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects: - Burning or stinging at the application site. - Pruritus (itching). - Erythema or redness of the skin. - Dryness or peeling of the treated area. - Contact dermatitis. - Mild scaling.

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis, angioedema). - Hepatotoxicity with systemic absorption (rare). - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Photosensitivity reactions. - Secondary bacterial infection of the skin.

Ketoconazole should be used with attention to patient safety and proper handling. - Contraindication: Do not use on patients with known hypersensitivity to azole antifungals. - Pregnancy: Avoid use unless clearly needed; consult a healthcare professional. - Breastfeeding: Caution advised; discuss risks with a physician. - Application: Apply a thin layer to clean, dry skin and avoid occlusion unless directed. - Interaction: Monitor for systemic absorption when used over large areas or broken skin. - Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Ketoconazole may interact with other medications, especially those affecting cytochrome P450 enzymes.

Major Interactions (Avoid): - Systemic CYP3A4 inhibitors (e.g., ketoconazole oral, itraconazole): may increase systemic exposure. - Hepatotoxic drugs (e.g., isoniazid, methotrexate): heightened risk of liver injury.

Moderate Interactions (Monitor Closely): - Topical corticosteroids: may increase skin absorption of ketoconazole. - Other topical antifungals: assess for additive irritation. - Warfarin: monitor INR if extensive skin application leads to systemic absorption.