Keto-Cure

Ketoconazole, the active ingredient in Keto-Cure, is an azole antifungal presented as a topical formulation for cutaneous use. It treats superficial fungal skin infections such as tinea corporis, tinea cruris and seborrheic dermatitis in both adults and children, providing a localized approach to eradicate dermatophytes and yeasts.

GNH USA supplies Keto-Cure as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU pharmaceutical standards and is distributed under strict quality controls. Distribution is managed through a reliable supply chain ensuring product integrity.

Ketoconazole is an azole antifungal that targets dermatophyte and yeast infections of the skin.

- Tinea corporis: clears the infection and reduces scaling and redness. - Tinea cruris: alleviates itching and resolves the fungal rash in the groin area. - Seborrheic dermatitis: reduces flaking, erythema and fungal colonisation on the scalp and face. - Other superficial fungal skin infections: treats various cutaneous candidiasis and dermatophytosis presentations.

Ketoconazole topical preparations may cause local and, rarely, systemic adverse reactions.

Common Side Effects: - Skin irritation: mild redness, burning or itching at the application site, usually transient. - Dryness: temporary dryness or peeling of the treated skin area. - Pruritus: increased itching that may persist during treatment. - Contact dermatitis: allergic skin reaction presenting as a localized rash and swelling.

Serious or Rare Side Effects: - Hepatotoxicity: rare systemic absorption may cause elevated liver enzymes or hepatitis. - Severe allergic reaction: anaphylaxis or angioedema requiring immediate emergency care. - Photosensitivity: heightened sensitivity to sunlight leading to sunburn‑like lesions. - Secondary infection: overgrowth of bacteria or resistant fungi at the application site.

When using Ketoconazole topical products, certain precautions should be observed to ensure safety and effectiveness. - Avoid use on broken skin: do not apply to open wounds or extensive abrasions. - Limit duration: prolonged use beyond recommended period may increase risk of irritation. - Pediatric use: consult a healthcare professional before treating children under two years. - Pregnancy and lactation: discuss potential risks with a physician, as safety data are limited. - Drug interactions: inform the prescriber of concurrent use of other topical or systemic antifungals. - Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Ketoconazole can interact with other medicines; awareness of these interactions helps prevent reduced efficacy or increased toxicity.

Major Interactions (Avoid): - Systemic azoles: concurrent systemic azole antifungals may cause additive toxicity. - CYP3A4 inhibitors: strong inhibitors (e.g., oral ketoconazole, itraconazole) can increase systemic absorption leading to hepatotoxicity.

Moderate Interactions (Monitor Closely): - Topical steroids: may mask signs of infection, requiring monitoring. - Warfarin: ketoconazole may enhance anticoagulant effect, necessitating INR checks. - Oral contraceptives: possible reduction in efficacy, advise alternative contraception.