Ketazed (Ketotifen Hydrogen Fumarate)

Ketotifen hydrogen fumarate, the active ingredient in Ketazed, is an antihistamine (mast cell stabilizer) presented as an ophthalmic preparation for ocular use. It is employed to manage allergic conjunctivitis and related seasonal allergic eye conditions in patients requiring topical therapy.

GNH USA supplies Ketazed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketazed acts on ocular allergic pathways to relieve inflammation and itching associated with allergic eye disease. - Allergic conjunctivitis: reduces ocular itching, redness, and tearing. - Seasonal allergic eye disease: stabilises mast cells to prevent episodic symptoms during pollen seasons. - Vernal keratoconjunctivitis: helps control chronic inflammation and photophobia in severe seasonal forms.

Ketazed may cause ocular and systemic reactions in some patients.

Common Side Effects: - Burning or stinging sensation upon instillation. - Transient blurred vision. - Mild eye irritation or redness. - Dry eye sensation. - Headache. - Temporary increased tearing.

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) with swelling of eyelids or face. - Corneal ulcer or keratitis. - Persistent intra‑ocular inflammation. - Vision loss. - Severe eye pain. - Acute hypersensitivity dermatitis around the eye.

Before using Ketazed, consider the following safety measures. - Pregnancy: consult a healthcare professional before use. - Breastfeeding: discuss potential risks with a physician. - Contact lens wearers: avoid use unless advised by an eye specialist. - Existing ocular infection: evaluate and treat infection prior to administration. - Concomitant ocular medications: assess for possible interactions. - Store at below 25°C: keep in the original container, protect from light and moisture.

Ketazed may interact with other ocular or systemic agents.

Major Interactions (Avoid): - No major drug interactions have been identified for ocular use of ketotifen.

Moderate Interactions (Monitor Closely): - Systemic antihistamines: may increase ocular dryness. - Topical corticosteroids: could mask signs of infection. - Other mast cell stabilizers: additive effect may increase local irritation. - Beta‑blocker eye drops: monitor intra‑ocular pressure if used together. - Preservative‑containing drops: may enhance irritation when combined.