Kestine

Ebastine, the active ingredient in Kestine, is a second‑generation H1 antihistamine presented as an oral tablet for oral use. It treats allergic rhinitis and chronic idiopathic urticaria in adults and adolescents.

GNH USA supplies Kestine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Kestine (ebastine) is used to manage allergic conditions by blocking peripheral H1 receptors.

- Allergic rhinitis: relieves nasal congestion, sneezing, itching and watery discharge. - Seasonal allergic rhinitis: reduces symptoms triggered by pollen or outdoor allergens. - Chronic idiopathic urticaria: diminishes hives and associated itching, improving quality of life.

Adverse reactions to ebastine are generally mild, but patients should be aware of possible side effects.

Common Side Effects: - Headache: mild to moderate intensity. - Dry mouth: transient sensation of oral dryness. - Drowsiness: occasional mild sedation. - Gastrointestinal discomfort: nausea or abdominal pain.

Serious or Rare Side Effects: - Cardiac arrhythmia: rare reports of QT prolongation. - Severe skin reactions: such as Stevens‑Johnson syndrome. - Anaphylaxis: extremely rare but potentially life‑threatening hypersensitivity.

Before prescribing ebastine, clinicians should consider several safety aspects.

- Pregnancy: use only if the potential benefit justifies the potential risk to the fetus. - Breastfeeding: assess risk versus benefit, as the drug may pass into milk. - Hepatic impairment: dose adjustment may be required in severe liver disease. - Concomitant CNS depressants: monitor for additive sedation. - Elderly patients: start at the lowest effective dose and monitor closely. - Store at ambient temperature: keep below 25 °C, retain in the original container, and protect from moisture.

Ebastine may interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase ebastine plasma levels. - Erythromycin: can raise systemic exposure and risk of cardiac effects.

Moderate Interactions (Monitor Closely): - Alcohol: may enhance drowsiness. - Other antihistamines: risk of additive anticholinergic effects. - CNS depressants (e.g., benzodiazepines): monitor for increased sedation.