Kestine

Ebastine, the active ingredient in Kestine, is a second‑generation H1 antihistamine presented as an oral tablet for oral use. It treats allergic rhinitis and chronic idiopathic urticaria in adults and adolescents.

GNH USA supplies Kestine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ebastine is a second‑generation H1 antihistamine used to manage allergic conditions affecting the nasal passages and skin.

Allergic rhinitis: reduces nasal congestion, sneezing, itching and watery discharge. Chronic idiopathic urticaria: alleviates hives, itching and swelling of the skin.

Adverse reactions may occur with ebastine therapy.

Common Side Effects: - Headache - Dry mouth - Drowsiness - Nausea

Serious or Rare Side Effects: - Angioedema - Severe skin reactions such as Stevens‑Johnson syndrome - Anaphylactic shock

Before prescribing ebastine, consider the following safety measures.

Assess hepatic function: evaluate liver enzymes in patients with known liver disease. Monitor for sedation: observe patients who may experience drowsiness, especially when driving. Avoid in known hypersensitivity: discontinue if allergic reactions develop. Caution in the elderly: start at the lowest effective dose and monitor closely. Use with caution in renal impairment: dose adjustment may be required. Store at below 25°C: keep in the original pack, protect from moisture.

Ebastine may interact with other medicines; review patient medication lists.

Major Interactions (Avoid): - Ketoconazole: may increase ebastine plasma concentrations. - Ritonavir: can markedly raise ebastine levels, raising risk of toxicity.

Moderate Interactions (Monitor Closely): - Alcohol: may enhance sedative effects. - Other antihistamines: additive antihistaminic activity may increase drowsiness. - CNS depressants: monitor for enhanced central sedation.