Kestine

Ebastine, the active ingredient in Kestine, is a second‑generation H1‑receptor antagonist presented as a 10 mg oral tablet for oral use. It is used to treat allergic rhinitis and chronic idiopathic urticaria in adults and adolescents, providing relief from nasal congestion, itching, sneezing, and hives.

GNH USA supplies Kestine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and ensures batch consistency for global distribution.

Ebastine is indicated for allergic conditions that involve histamine‑mediated responses. Allergic rhinitis: alleviates nasal congestion, sneezing, itching and rhinorrhea. Chronic idiopathic urticaria: reduces frequency and severity of wheals and itching. Seasonal allergic rhinitis: provides symptom control during pollen exposure.

Like all antihistamines, Ebastine may cause adverse reactions, which are generally mild but can be serious in rare cases.

Common Side Effects: - Headache - Dry mouth - Drowsiness - Fatigue - Gastrointestinal discomfort - Dizziness

Serious or Rare Side Effects: - Angioedema - Severe skin rash (e.g., Stevens‑Johnson syndrome) - Anaphylactic reaction - Cardiac arrhythmia - Hepatotoxicity - Blood dyscrasias such as agranulocytosis

Before prescribing Ebastine, clinicians should consider several safety aspects. Hepatic function: assess liver status prior to initiation. Renal impairment: use with caution and consider dose adjustment. Known hypersensitivity: avoid in patients allergic to ebastine or excipients. Pregnancy: consult a healthcare provider before use. Breastfeeding: weigh potential risks and benefits. Elderly: start at the lowest effective dose and monitor closely. Store at ambient temperature: keep in original packaging, protect from moisture and heat.

Ebastine can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Ketoconazole: may increase plasma ebastine concentrations. - Erythromycin: can raise ebastine levels and enhance side effects. - Ritonavir: may significantly elevate ebastine exposure.

Moderate Interactions (Monitor Closely):\n- Theophylline: possible increase in theophylline side effects. - Alcohol: may enhance drowsiness and sedation. - Other antihistamines: additive sedative effects may occur.