Kestine

Ebastine, the active ingredient in Kestine, is a second‑generation H1‑receptor antagonist presented as an oral tablet for oral use. It is indicated for the relief of symptoms associated with allergic rhinitis and chronic urticaria in adults and adolescents.

GNH USA supplies Kestine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ebastine is used to manage allergic conditions by blocking peripheral H1 receptors.

- Allergic rhinitis: reduces nasal congestion, sneezing, itching and watery discharge. - Chronic urticaria: alleviates hives and associated itching. - Histamine‑mediated allergic symptoms: provides overall symptomatic relief of itching and swelling.

Ebastine may cause adverse reactions, which are categorized by frequency and severity.

Common Side Effects: - Headache - Dry mouth - Drowsiness - Fatigue - Gastro‑intestinal discomfort - Dizziness

Serious or Rare Side Effects: - Cardiac arrhythmia - Severe skin reactions such as Stevens‑Johnson syndrome - Anaphylaxis - Hepatic injury - Blood dyscrasias

Before prescribing ebastine, consider the following safety measures.

- Pregnancy: safety not established; use only if clearly needed. - Breastfeeding: unknown excretion; weigh benefits against potential risks. - Elderly: monitor for increased sedation or dizziness. - Concomitant CYP3A4 inhibitors: may raise plasma levels; adjust therapy as needed. - Renal or hepatic impairment: dose adjustment may be required. - Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture and direct sunlight.

Ebastine can interact with other medicines; awareness of interaction severity helps guide therapy.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase ebastine concentrations. - Co‑administration with other H1 antagonists: can lead to additive sedation.

Moderate Interactions (Monitor Closely): - CYP3A4 inducers (e.g., rifampicin): may reduce ebastine effectiveness. - Alcohol: may enhance drowsiness. - Theophylline: may increase plasma levels of ebastine.