Kestine

Ebastine, the active ingredient in Kestine, is an antihistamine presented as an oral tablet for oral use. As a selective peripheral H1‑receptor antagonist, it alleviates symptoms of allergic rhinitis and chronic urticaria in adults and adolescents across the European market.

GNH USA supplies Kestine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for allergy management products. All batches are manufactured under EU Good Manufacturing Practice and undergo stringent quality testing before release.

Ebastine is used to manage allergic conditions by blocking peripheral H1 receptors.

Allergic rhinitis: reduces nasal congestion, sneezing, itching and watery discharge. Chronic urticaria: decreases frequency and severity of hives and associated itching. Allergic conjunctivitis: alleviates eye itching and redness associated with allergic reactions.

Common Side Effects: - Headache - Dry mouth - Drowsiness - Gastrointestinal discomfort - Fatigue - Dizziness

Serious or Rare Side Effects: - Anaphylactic reactions - Cardiac arrhythmias - Elevated liver enzymes - Blood dyscrasias - Stevens‑Johnson syndrome - Hemolytic anemia

Before initiating therapy, consider the following precautions: - Assess patient history: check for known hypersensitivity to ebastine or other antihistamines. - Avoid use in severe hepatic impairment: dose adjustment may be required. - Caution in patients with renal dysfunction: monitor renal function. - Consider pregnancy status: safety not established, use only if benefit outweighs risk. - Avoid concomitant use with potent CYP3A4 inhibitors: may increase plasma levels. - Store at ambient temperature: keep below 25°C, protect from moisture and light.

Ebastine may interact with several medicines; review the following:

Major Interactions (Avoid): - Potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase ebastine levels and risk of cardiac effects. - Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy. - Other antihistamines: additive sedation.

Moderate Interactions (Monitor Closely): - Alcohol: may enhance drowsiness. - CNS depressants (e.g., benzodiazepines): may increase sedation. - Theophylline: may alter metabolism of ebastine.