Kestine (Ebastine)

Ebastine, the active ingredient in Kestine, is a second‑generation H1 antihistamine presented as an oral dosage form for oral use. It is indicated for the treatment of allergic rhinitis and chronic idiopathic urticaria in patients requiring relief from histamine‑mediated symptoms.

GNH USA supplies Kestine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ebastine acts on the histamine‑H1 pathway to alleviate allergic conditions. - Allergic rhinitis: reduces nasal congestion, sneezing and itching caused by seasonal or perennial allergens. - Chronic idiopathic urticaria: diminishes the frequency and severity of hives and associated itching. - Allergic skin itching: provides symptomatic relief of itching due to allergic reactions.

Adverse reactions may occur with ebastine therapy.

Common Side Effects: - Headache: mild to moderate intensity. - Drowsiness: occasional sedation, especially at higher doses. - Dry mouth: reduced salivation. - Nausea: transient gastrointestinal discomfort.

Serious or Rare Side Effects: - Angioedema: swelling of face, lips or throat requiring urgent care. - Severe rash or Stevens‑Johnson syndrome: extensive skin involvement. - Hepatitis: elevated liver enzymes or jaundice. - Anaphylaxis: rapid onset of systemic allergic reaction. - Cardiac arrhythmia: rare but reported in susceptible individuals.

Before initiating ebastine, consider the following precautions. - Assess hepatic function: adjust use in patients with liver impairment. - Avoid in patients with known hypersensitivity to ebastine or other antihistamines. - Caution in renal impairment: monitor renal function periodically. - Monitor for sedation: advise patients not to operate machinery if drowsy. - Store at ambient temperature: keep in the original pack, protect from moisture.

Ebastine may interact with other medicines; review patient medication lists.

Major Interactions (Avoid): - Ketoconazole: can increase ebastine plasma concentrations. - Ritonavir: may elevate ebastine levels, raising risk of side effects. - Erythromycin: potential to raise systemic exposure.

Moderate Interactions (Monitor Closely): - Theophylline: may reduce its bronchodilator effect. - Alcohol: can enhance drowsiness. - Other antihistamines: additive sedation may occur.