Kestine 10

Ebastine, the active ingredient in Kestine 10, is a second‑generation H1 antihistamine presented as a tablet for oral use. It alleviates symptoms of allergic rhinitis and chronic urticaria in adults and adolescents.

GNH USA supplies Kestine 10 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets. The product complies with European Union pharmacopeial standards and is manufactured under GMP conditions, providing consistent potency and safety for patients through rigorous quality control procedures.

Ebastine is indicated for allergic conditions that involve histamine‑mediated responses. - Allergic rhinitis: relief of nasal congestion, sneezing, itching and rhinorrhea. - Seasonal allergic rhinitis: control of symptoms during pollen exposure. - Chronic urticaria: reduction of wheal formation and itching.

Ebastine is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Headache - Drowsiness - Dry mouth - Fatigue - Nausea - Dizziness

Serious or Rare Side Effects: - Anaphylaxis (severe allergic reaction) - Cardiac arrhythmia - Hepatotoxicity - Blood dyscrasias such as neutropenia - Stevens‑Johnson syndrome

Before prescribing ebastine, consider the following precautions. - Avoid use with potent CYP3A4 inhibitors: may increase plasma levels. - Caution in patients with hepatic impairment: dose adjustment may be required. - Use with care in the elderly: increased sensitivity to sedation. - Do not operate machinery if drowsiness occurs: monitor functional ability. - Pregnancy and lactation: safety not established, consult specialist. - Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Ebastine may interact with other medicines, requiring attention to the following.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): can markedly raise ebastine levels. - Antifungal agents such as itraconazole: increase exposure. - Monoamine oxidase inhibitors: may enhance antihistaminic effects.

Moderate Interactions (Monitor Closely): - Alcohol: may increase drowsiness. - CNS depressants (benzodiazepines, opioids): additive sedation. - Other antihistamines: risk of cumulative anticholinergic effects.