Keratosis

Urea, the active ingredient in Keratosis, is a keratolytic / humectant presented as a topical formulation for topical use. It helps manage keratosis, hyperkeratosis, dry skin and ichthyosis in adult patients and can be applied to affected areas once or twice daily as directed by a healthcare professional.

GNH USA supplies Keratosis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Keratosis is used topically to treat hyperkeratotic skin conditions and dryness.

Keratosis: reduces thickened plaques and improves skin smoothness. Hyperkeratosis: softens excess keratin and promotes desquamation. Dry skin: enhances hydration and barrier function. Ichthyosis: decreases scaling and improves skin texture.

Topical urea may cause local skin reactions, ranging from mild irritation to rare severe events.

Common Side Effects: - Skin irritation: mild redness or discomfort at the application site. - Burning sensation: transient warmth after application. - Itching: occasional pruritus. - Dryness: temporary increase in skin dryness.

Serious or Rare Side Effects: - Allergic contact dermatitis: swelling, rash, or hives requiring medical attention. - Blister formation: localized vesicles that may become infected. - Systemic absorption leading to electrolyte imbalance: extremely rare but reported with extensive use.

Before using Keratosis, consider the following precautions to ensure safe and effective treatment.

Pregnancy: safety not established; consult a healthcare professional before use. Breastfeeding: unknown safety; use only if benefit outweighs potential risk. Open wounds: avoid application on broken or infected skin to prevent irritation. Concurrent keratolytics: limit combined use with other strong keratolytic agents to reduce irritation risk. Children: safety not established; use under medical supervision if prescribed. Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Keratosis may interact with other topical agents, affecting skin tolerance or drug absorption.

Major Interactions (Avoid): - Topical retinoids: increased irritation and peeling. - Salicylic acid preparations: heightened skin irritation. - Occlusive dressings: may enhance systemic absorption of urea.

Moderate Interactions (Monitor Closely): - Other moisturizers: may dilute efficacy; monitor skin response. - Topical corticosteroids: may reduce inflammation but also alter urea penetration; observe for changes.