Keratosis + Tretinoin (Tretinoin, Urea)

Tretinoin and urea, the active ingredients in Keratosis + Tretinoin, are a retinoid and a keratolytic presented as a topical formulation for skin application. The combination promotes desquamation of hyperkeratotic lesions and softens the stratum corneum, helping to manage keratosis and related disorders in adult patients.

GNH USA supplies Keratosis + Tretinoin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Keratosis + Tretinoin is used in dermatology to treat disorders characterized by abnormal keratinization.

- Keratosis: reduces hyperkeratotic plaques and improves skin texture. - Hyperkeratosis: softens thickened skin and promotes normal shedding. - Psoriasis (adjunctive): assists in reducing scaling when used alongside standard therapy. - Acne vulgaris (off‑label): may help clear comedonal lesions by normalizing follicular epithelium.

Topical application of Keratosis + Tretinoin may cause local skin reactions.

Common Side Effects: - Erythema: mild redness at the application site. - Peeling: flaking or scaling of treated skin. - Dryness: transient skin dryness or tightness. - Burning sensation: temporary stinging on first use.

Serious or Rare Side Effects: - Severe dermatitis: extensive inflammation requiring medical attention. - Allergic contact dermatitis: rash, swelling, or urticaria. - Photosensitivity: increased sensitivity to sunlight leading to sunburn.

Before using Keratosis + Tretinoin, consider the following precautions.

- Pregnancy: safety not established; avoid use unless clearly needed. - Breastfeeding: unknown risk; consider alternative therapy. - Sun exposure: limit UV exposure and use sunscreen due to increased photosensitivity. - Pre‑existing skin conditions: avoid on eczematous or inflamed skin to reduce irritation. - Concomitant retinoids: do not combine with other topical retinoids to prevent excess irritation. - Store at ambient temperature: keep below 25 °C, in original container, protected from moisture and light.

Keratosis + Tretinoin may interact with other medicines or substances.

Major Interactions (Avoid): - Systemic retinoids: concurrent use may increase risk of toxicity. - Photosensitizing agents (e.g., tetracyclines): may exacerbate photosensitivity. - Topical corticosteroids: may reduce efficacy of tretinoin.

Moderate Interactions (Monitor Closely): - Antifungal creams containing azoles: may alter skin barrier and affect absorption. - Vitamin A supplements: monitor for cumulative retinoid effect. - Skin irritants (e.g., alpha‑hydroxy acids): may increase irritation.