Keplat

Ketoprofen, the active ingredient in Keplat, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a transdermal patch for topical administration. It provides analgesic and anti‑inflammatory effects for the relief of mild to moderate pain associated with musculoskeletal disorders, osteoarthritis and rheumatoid arthritis in adult patients.

GNH USA supplies Keplat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Ketoprofen is used to manage pain and inflammation in several musculoskeletal and arthritic conditions.

- Musculoskeletal pain: reduces pain and improves function in acute and chronic muscle or joint discomfort. - Osteoarthritis: alleviates joint pain and stiffness, enhancing mobility. - Rheumatoid arthritis: helps control inflammatory pain and swelling in affected joints.

Ketoprofen transdermal patches may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Skin irritation at application site: redness, itching or rash. - Localized burning or stinging sensation. - Mild headache. - Gastrointestinal discomfort: nausea or dyspepsia. - Dizziness.

Serious or Rare Side Effects: - Severe allergic reaction: swelling of face, lips or throat, hives. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Gastrointestinal ulceration or bleeding. - Renal impairment or sudden decrease in kidney function. - Hepatotoxicity with elevated liver enzymes.

When using Ketoprofen patches, certain precautions should be observed to minimize risks.

- Assess renal function: avoid use in patients with severe renal impairment. - Evaluate hepatic status: use cautiously in liver disease. - Monitor cardiovascular risk: NSAIDs may increase risk of thrombotic events. - Avoid concurrent use with other NSAIDs or anticoagulants without medical advice. - Check for hypersensitivity: discontinue if signs of allergic reaction appear. - Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Ketoprofen may interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity. - Corticosteroids: additive risk of ulceration.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in renal function. - Diuretics: may exacerbate renal impairment. - Lithium: NSAIDs can raise lithium levels. - Methotrexate: reduced clearance leading to toxicity.