Keplat

Ketoprofen, the active ingredient in Keplat, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as a transdermal patch for transdermal use. It provides analgesic and anti‑inflammatory effects for musculoskeletal conditions such as osteoarthritis and other painful inflammatory disorders.

GNH USA supplies Keplat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen acts on inflammatory pathways to relieve pain and swelling in the musculoskeletal system.

- Musculoskeletal pain: reduces pain and improves mobility in muscles and joints. - Osteoarthritis: alleviates joint discomfort and supports functional activity. - Acute inflammation: diminishes swelling and erythema associated with soft‑tissue injuries. - Post‑operative pain: provides localized analgesia after minor surgical procedures.

Ketoprofen transdermal patches may cause a range of adverse reactions.

Common Side Effects: - Skin irritation at the application site: redness, itching, or mild rash. - Localized itching or burning sensation. - Headache. - Mild gastrointestinal discomfort.

Serious or Rare Side Effects: - Severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Gastrointestinal ulceration or bleeding. - Hepatic dysfunction or elevated liver enzymes. - Renal impairment, especially in patients with pre‑existing kidney disease. - Cardiovascular events including hypertension or thrombotic episodes. - Anaphylactic reactions requiring emergency care.

When using Ketoprofen patches, several safety considerations are recommended.

- Renal function assessment: evaluate kidney health before initiating therapy. - Hepatic monitoring: check liver enzymes periodically during prolonged use. - Cardiovascular caution: avoid in patients with uncontrolled hypertension or recent cardiovascular events. - NSAID hypersensitivity: do not use in individuals with known allergy to ketoprofen or other NSAIDs. - Application site: avoid placing the patch on broken, infected, or irritated skin. - Store at room temperature: keep in the original packaging, protect from moisture and direct heat.

Ketoprofen may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid): - Warfarin: increased risk of bleeding. - ACE inhibitors (e.g., captopril): potential reduction in renal function. - Lithium: heightened lithium toxicity.

Moderate Interactions (Monitor Closely): - SSRIs (e.g., sertraline): additive bleeding risk. - Diuretics (e.g., furosemide): may affect renal clearance of ketoprofen.