Keplat

Ketoprofen, the active ingredient in Keplat, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a transdermal patch for transdermal use. It provides relief of mild to moderate pain and reduces inflammation in musculoskeletal conditions such as osteoarthritis, rheumatoid arthritis, and sports injuries. The patch delivers ketoprofen systemically through the skin, allowing continuous drug exposure over several hours.

GNH USA supplies Keplat as a licensed, GDP‑compliant international pharmaceutical supplier, adhering to EU GMP standards and providing quality‑assured medicines to hospitals, pharmacies and clinics worldwide.

Ketoprofen, an NSAID that inhibits cyclooxygenase enzymes, is used for the following musculoskeletal and inflammatory conditions:

- Osteoarthritis: reduces joint pain and inflammation, improving mobility. - Rheumatoid arthritis: alleviates chronic joint inflammation and associated discomfort. - Sports injuries: provides analgesic and anti‑inflammatory effects to support recovery after sprains, strains or overuse injuries.

Ketoprofen may cause a range of adverse reactions, most of which are related to its NSAID class.

Common Side Effects: - Skin irritation at the patch site: redness, itching or mild rash. - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness: transient sensation of light‑headedness.

Serious or Rare Side Effects: - Severe allergic reaction: swelling of face, lips or throat, hives. - Gastrointestinal ulcer or bleeding: black stools, vomiting blood. - Renal impairment: reduced urine output, swelling of limbs. - Hepatotoxicity: jaundice, elevated liver enzymes. - Cardiovascular events: chest pain, shortness of breath.

When using Ketoprofen transdermal patches, consider the following safety measures:

- Hypersensitivity: avoid in patients with known allergy to ketoprofen or other NSAIDs. - Gastrointestinal risk: use cautiously in individuals with a history of ulcers or bleeding. - Renal function: monitor kidney parameters in patients with pre‑existing renal disease. - Elderly patients: start with the lowest effective dose due to increased susceptibility to adverse effects. - Pregnancy and lactation: assess risk‑benefit ratio; use only if clearly needed. - Store at room temperature (below 25°C): keep in the original packaging, protect from moisture and direct sunlight.

Ketoprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce renal protective effects, monitor kidney function. - Diuretics: potential for reduced diuretic efficacy and renal impairment. - Lithium: NSAIDs can increase lithium serum levels, requiring close monitoring.