Kendo

Ibuprofen, the active ingredient in Kendo, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a tablet for oral use. It is used to relieve pain, reduce fever, and lessen inflammation in adults and children as directed by a healthcare professional.

GNH USA supplies Kendo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen acts systemically to manage common inflammatory and pain‑related conditions. - Pain: provides analgesic relief for mild to moderate acute pain such as headache, dental pain, or musculoskeletal discomfort. - Fever: reduces elevated body temperature associated with infections or inflammatory states. - Inflammation: alleviates swelling and discomfort in conditions like arthritis, sprains, or soft‑tissue injuries.

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia, or mild abdominal pain. - Headache: transient headache not related to the underlying condition. - Dizziness: occasional light‑headedness or vertigo. - Rash: mild skin redness or itching. - Elevated blood pressure: modest increase in systolic or diastolic pressure. - Fluid retention: mild peripheral edema.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding: severe abdominal pain, melena, or hematemesis. - Renal impairment: reduced urine output, swelling, or elevated creatinine. - Hepatotoxicity: jaundice, dark urine, or elevated liver enzymes. - Severe allergic reactions: anaphylaxis, angioedema, or widespread rash. - Cardiovascular events: increased risk of myocardial infarction or stroke, especially with high‑dose or prolonged use.

When considering ibuprofen therapy, several safety measures should be observed. - Contraindications: avoid use in patients with known hypersensitivity to ibuprofen or other NSAIDs. - Gastrointestinal risk: use caution in individuals with a history of ulcers, gastritis, or bleeding disorders. - Renal function: monitor kidney function in patients with chronic kidney disease or dehydration. - Cardiovascular health: assess cardiovascular risk in patients with hypertension, heart failure, or prior thrombotic events. - Pregnancy and lactation: consult a healthcare professional before use during pregnancy or breastfeeding. - Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture and direct sunlight.

Ibuprofen can interact with several drug classes, influencing efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - High‑dose aspirin: heightened gastrointestinal toxicity. - Selective COX‑2 inhibitors: additive renal and cardiovascular adverse effects.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function. - Diuretics: may enhance renal impairment. - Lithium: ibuprofen can raise serum lithium levels, requiring monitoring. - Methotrexate: reduced clearance leading to toxicity. - Corticosteroids: increased risk of gastrointestinal ulceration.