Keforal

Cefalexin, the active ingredient in Keforal, is a first‑generation cephalosporin presented as a tablet for oral use. It treats bacterial infections of the skin, respiratory tract, urinary system, and bone and joint in both adults and children as prescribed.

GNH USA supplies Keforal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Keforal, a cephalosporin antibiotic, is employed to combat bacterial infections in several organ systems.

- Skin and soft‑tissue infections: eradicates susceptible pathogens and promotes healing of cellulitis and impetigo. - Respiratory tract infections: treats acute bronchitis, sinusitis, and community‑acquired pneumonia caused by susceptible bacteria. - Urinary tract infections: eliminates causative organisms in cystitis and uncomplicated pyelonephritis. - Bone and joint infections: assists in resolving osteomyelitis and septic arthritis when appropriate.

Adverse reactions may occur with cefalexin therapy.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Diarrhea: loose stools, occasionally watery. - Abdominal pain: cramping or discomfort. - Rash: mild skin erythema or itching. - Headache: transient mild headache. - Vomiting: occasional emesis.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction with airway compromise. - Stevens‑Johnson syndrome: rare severe skin and mucosal lesions. - Clostridioides difficile‑associated diarrhea: severe colitis. - Hematologic abnormalities: neutropenia or thrombocytopenia. - Hepatic dysfunction: elevated liver enzymes. - Renal impairment: acute kidney injury in susceptible patients.

Before prescribing Keforal, consider the following precautions.

- Assess renal function: adjust dosage in patients with renal impairment. - Monitor for allergic reactions: discontinue immediately if severe hypersensitivity occurs. - Use with caution in patients with a history of colitis: risk of C. difficile infection. - Avoid in individuals with known hypersensitivity to cephalosporins or penicillins. - Store at ambient temperature: keep in the original pack, protect from moisture.

Cefalexin may interact with other medicines; review the following.

Major Interactions (Avoid): - Probenecid: can increase cefalexin plasma concentrations, raising toxicity risk. - Live bacterial vaccines: may reduce vaccine efficacy.

Moderate Interactions (Monitor Closely): - Warfarin: may enhance anticoagulant effect, requiring INR monitoring. - Oral contraceptives: possible reduction in contraceptive effectiveness. - Antacids containing aluminum or magnesium: may decrease cefalexin absorption if taken simultaneously.