Keflex

Cefalexin Monohydrate, the active ingredient in Keflex, is a cephalosporin presented as an oral dosage form for systemic use. It is used to treat bacterial infections of the upper respiratory tract, skin and soft tissues, and the urinary system in adults and children as prescribed by a healthcare professional.

GNH USA supplies Keflex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with established quality‑assured manufacturing and distribution networks across Europe and other markets globally.

Keflex (cefalexin monohydrate) is a cephalosporin antibiotic indicated for bacterial infections affecting specific organ systems.

Upper respiratory tract infections: treatment of acute bacterial sinusitis, pharyngitis, and tonsillitis caused by susceptible organisms. Skin and soft tissue infections: therapy for cellulitis, impetigo, and wound infections due to susceptible bacteria. Urinary tract infections: management of uncomplicated cystitis and pyelonephritis caused by susceptible strains.

Adverse reactions may occur with cefalexin use. Monitoring and reporting are recommended.

Common Side Effects: - Gastrointestinal upset: nausea, vomiting, abdominal pain. - Diarrhea: mild to moderate loose stools. - Skin rash: mild erythema or pruritus. - Headache.

Serious or Rare Side Effects: - Clostridioides difficile‑associated colitis: severe diarrhea and colitis. - Hypersensitivity reactions: anaphylaxis, Stevens‑Johnson syndrome. - Hepatotoxicity: elevated liver enzymes or jaundice.

Before prescribing cefalexin, consider the following precautions. - Renal impairment: dose adjustment may be required. - Allergy history: avoid if known cephalosporin or penicillin allergy. - Pregnancy and lactation: use only if benefits outweigh risks. - Drug interactions: monitor concomitant use with anticoagulants or oral contraceptives. - Microbiological resistance: limit use to confirmed susceptible infections. - Store at ambient temperature: keep in original container, protect from moisture and heat.

Cefalexin may interact with other medicines; some combinations require avoidance while others need monitoring.

Major Interactions (Avoid): - Probenecid: may increase cefalexin plasma concentrations, raising toxicity risk. - Anticoagulants (warfarin): may enhance anticoagulant effect, monitor INR closely. - Oral contraceptives: may reduce efficacy, advise alternative contraception.

Moderate Interactions (Monitor Closely): - Aminoglycosides: concurrent nephrotoxic potential, monitor renal function. - Diuretics: may affect renal clearance, observe renal parameters. - Allopurinol: may increase risk of rash.