Keflex

Cefalexin, the active ingredient in Keflex, is a first‑generation cephalosporin presented as an oral tablet for oral use. It treats bacterial infections of the skin, urinary tract, respiratory system and bone in adult and pediatric patients as prescribed by a healthcare professional. It is indicated for a range of infections and is commonly used in outpatient and inpatient settings under medical supervision.

GNH USA supplies Keflex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality assurance and regulatory compliance across all markets.

Cefalexin (Keflex) is a first‑generation cephalosporin antibiotic that targets bacterial infections of various organ systems.

- Skin and soft tissue infections: effective in treating bacterial infections of the skin and underlying tissues. - Urinary tract infections: used to eradicate common uropathogens causing cystitis and pyelonephritis. - Respiratory tract infections: indicated for bacterial sinusitis, bronchitis and community‑acquired pneumonia. - Bone and joint infections: employed in the management of osteomyelitis and septic arthritis caused by susceptible organisms.

Cefalexin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Diarrhea: mild to moderate loose stools. - Nausea: feeling of stomach upset. - Vomiting: expulsion of stomach contents. - Rash: mild skin erythema or itching. - Headache: transient cranial discomfort. - Abdominal pain: crampy discomfort in the stomach area.

Serious or Rare Side Effects: - Anaphylaxis: severe, life‑threatening allergic reaction. - Clostridioides difficile‑associated colitis: severe diarrhea with abdominal pain. - Stevens‑Johnson syndrome: extensive skin blistering and mucosal involvement. - Blood dyscrasias: neutropenia, thrombocytopenia, or hemolytic anemia. - Hepatic enzyme elevation: abnormal liver function tests. - Renal impairment: reduced kidney function or interstitial nephritis.

When prescribing or dispensing Cefalexin, consider the following precautions to ensure safe use.

- Renal function assessment: adjust dose in patients with impaired kidney function. - Allergy history: avoid in patients with known hypersensitivity to cephalosporins or penicillins. - Superinfection risk: monitor for secondary infections such as Clostridioides difficile colitis. - Pregnancy and lactation: use only if benefits outweigh potential risks. - Drug interactions: review concomitant medications for potential interactions. - Store at room temperature: keep in the original container, protect from moisture.

Cefalexin can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid): - Probenecid: may increase cefalexin plasma concentrations, raising toxicity risk. - Warfarin: can enhance anticoagulant effect, increasing bleeding tendency. - Live bacterial vaccines: may reduce vaccine efficacy.

Moderate Interactions (Monitor Closely): - Oral contraceptives: possible reduction in hormonal effectiveness. - Antacids containing aluminum or magnesium: may decrease cefalexin absorption. - Diuretics: potential for increased nephrotoxicity in susceptible patients.